Document Detail


Assessment of bone turnover in term and preterm newborns at birth: measurement of urinary collagen crosslink excretion.
MedLine Citation:
PMID:  10088987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured urinary excretion of collagen crosslinks, pyridinoline and deoxypyridinoline, in term and preterm newborns at birth and evaluated the developmental changes in bone turnover. Collagen crosslink excretion in newborns was more than 10 times higher than reported adult values and several times higher than those of older children. The values were significantly higher in preterm newborns than in term newborns. In addition, a significant and inverse correlation was found between urinary collagen crosslinks and gestational age in preterm newborns. Excretion of crosslinks during this period did not correlate with beta2-microglobulin, suggesting that the excretion was not directly influenced by renal function in newborns. We conclude that bone turnover assessed by measurement of collagen crosslink excretion is high at birth and that preterm newborns have higher bone turnover than term newborns.
Authors:
H Tsukahara; Y Watanabe; S Hirano; H Tsubokura; K Kimura; M Mayumi
Related Documents :
24698607 - Risk factors and rate of progression for zone i versus zone ii type 1 retinopathy of pr...
24000297 - Prospective risk factor monitoring reduces intracranial hemorrhage rates in preterm inf...
3651517 - Ketogenesis in hypoglycemic neonates. carnitine and dicarboxylic acids in neonatal hypo...
24650397 - Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of b...
410957 - Organochlorine poisoning of ring-billed gulls in southern ontario.
11036797 - Quality of life of mothers and families caring for preterm infants requiring home oxyge...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  53     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Faculty of Medicine, Fukui Medical University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / urine*
Birth Weight
Bone Remodeling*
Creatinine / urine
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Reference Values
beta 2-Microglobulin / urine
Chemical
Reg. No./Substance:
0/Amino Acids; 0/beta 2-Microglobulin; 60-27-5/Creatinine; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of maternal diabetes on the fetal exocrine pancreas.
Next Document:  Outcomes of children of extremely low birthweight and gestational age in the 1990's.