Document Detail

Assessment of bone turnover in term and preterm newborns at birth: measurement of urinary collagen crosslink excretion.
MedLine Citation:
PMID:  10088987     Owner:  NLM     Status:  MEDLINE    
We measured urinary excretion of collagen crosslinks, pyridinoline and deoxypyridinoline, in term and preterm newborns at birth and evaluated the developmental changes in bone turnover. Collagen crosslink excretion in newborns was more than 10 times higher than reported adult values and several times higher than those of older children. The values were significantly higher in preterm newborns than in term newborns. In addition, a significant and inverse correlation was found between urinary collagen crosslinks and gestational age in preterm newborns. Excretion of crosslinks during this period did not correlate with beta2-microglobulin, suggesting that the excretion was not directly influenced by renal function in newborns. We conclude that bone turnover assessed by measurement of collagen crosslink excretion is high at birth and that preterm newborns have higher bone turnover than term newborns.
H Tsukahara; Y Watanabe; S Hirano; H Tsubokura; K Kimura; M Mayumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  53     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Fukui Medical University, Japan.
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MeSH Terms
Amino Acids / urine*
Birth Weight
Bone Remodeling*
Creatinine / urine
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Reference Values
beta 2-Microglobulin / urine
Reg. No./Substance:
0/Amino Acids; 0/beta 2-Microglobulin; 60-27-5/Creatinine; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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