Document Detail


Assessment of blood flow in posterior ciliary arteries and its correlation with intraocular and arterial blood pressures in patients with open angle glaucoma.
MedLine Citation:
PMID:  20885367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: At present, the vascular theory of glaucomatous neuropathy is still the subject of intensive scientific studies aiming at settling the relationship between the development of glaucomatous neuropathy and vascular factors. Therefore the purpose of this study was to assess the blood flow parameters in the posterior ciliary artery and middle cerebral artery in patients with glaucoma and the correlation of glaucomatous changes with flow in vessels supplying the retina, choroid and anterior segment of the optic nerve in patients with glaucoma with and without coexisting arterial hypertension.
MATERIAL/METHODS: The study comprised 50 patients who were divided into two groups: group I - 25 patients (50 eyes) with primary open angle glaucoma (POAG) without coexisting arterial hypertension; and group II - 25 patients (50 eyes) with POAG with diagnosed and treated arterial hypertension.
RESULTS: The median of the mean maximal velocity in posterior ciliary arteries was 10.4 cm/s in patients from group I. In patients with POAG and arterial hypertension the median of the mean maximal velocity in posterior ciliary arteries was 8.95 cm/s (p<0.002). In group I the median of the Gosling pulsatility index (PI) in posterior ciliary arteries was 1.0, whereas in group II the median was 1.16 (p<0.002). The median of the pulsatility transmission index (PTI) for cerebral and ocular vessels was 1.3 in group I, whereas in group II the median was 1.38 (p<0.02).
CONCLUSIONS: The coexistence of arterial hypertension in glaucoma patients significantly worsens microcirculation in the area of posterior ciliary arteries and may be the cause of accelerated progression of glaucomatous neuropathy.
Authors:
Agnieszka Waliszek-Iwanicka; Marek Waliszek; Maciej Banach; Jacek Rysz; Roman Gos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-04-18     Revised Date:  2011-06-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR501-9     Citation Subset:  IM    
Affiliation:
Provincial Centre of Diabetology and Metabolic Diseases, M. Pirogow Hospital, Lodz, Poland. agnesc3@poczta.onet.pl
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Flow Velocity
Blood Pressure*
Cerebral Arteries / physiopathology*
Choroid / blood supply,  physiopathology,  ultrasonography
Eye / blood supply
Female
Glaucoma, Open-Angle / drug therapy,  physiopathology*,  ultrasonography
Humans
Intraocular Pressure*
Male
Middle Aged
Ocular Hypertension / physiopathology,  ultrasonography
Optic Nerve / blood supply*
Retina / physiopathology,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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