Document Detail

Assessment of biventricular functional reserve and NT-proBNP levels in patients with RV volume overload after repair of tetralogy of Fallot at young age.
MedLine Citation:
PMID:  18495276     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess biventricular functional reserve (FR), NT-proBNP levels and exercise performance, in relation to right ventricular volume in patients with pulmonary regurgitation (PR) after repair of tetralogy of Fallot (TOF) at young age. METHODS: In 53 TOF patients (maximum age at repair 2.0 years, interval since repair 15 (5) years) without residual lesions except PR, biventricular FR (derived from magnetic resonance imaging with dobutamine stress), NT-proBNP levels, maximal workload, and peak oxygen uptake were assessed. RESULTS: Mean right ventricular end-diastolic volume was 140(38) ml/m(2). Median pulmonary regurgitant fraction was 37% (range 0-57%). Biventricular systolic stress response was normal: mean (SD) ESV decreased (DeltaRVESV -17(8) ml/m(2), DeltaLVESV -11(5)), SV increased (DeltaRVSV +12(9) ml/m(2), DeltaLVSV +9(6)), FR was positive in all (RV-FR +11(5)%, LV-FR +13(6)). No serious adverse effects to dobutamine were encountered. NT-proBNP was increased in 2 patients. Median level was 10 pmol/L (range 2-42). NT-proBNP correlated with PR-percentage but not with right ventricular size. High-risk levels of NT-proBNP indicated a smaller RV-FR and a smaller decrease of biventricular ESV. Mean (SEM) VO2(max) was 96(3)%, mean Workload(max) 89(2)% of predicted. CONCLUSION: At mid to long term follow-up overall NT-proBNP levels are normal and biventricular functional reserve and exercise tolerance are well preserved in TOF repaired at young age, irrespective of RV volume. This questions the validity of isolated PR or RV volume criteria for pulmonary valve replacement in this group. Low-dose dobutamine stress testing is well tolerated and may be a useful additional tool for clinical decision making.
Jochem van den Berg; Jan L M Strengers; Piotr A Wielopolski; Wim C Hop; Folkert J Meijboom; Yolanda B de Rijke; Frans Boomsma; Ad J J C Bogers; Peter M T Pattynama; Willem A Helbing
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-05-20
Journal Detail:
Title:  International journal of cardiology     Volume:  133     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  364-70     Citation Subset:  IM    
Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Age Factors
Cohort Studies
Echocardiography, Doppler
Exercise Test / methods
Follow-Up Studies
Magnetic Resonance Imaging
Natriuretic Peptide, Brain / blood*,  physiology
Peptide Fragments / blood*,  physiology
Recovery of Function / physiology*
Stroke Volume / physiology
Tetralogy of Fallot / blood*,  surgery*
Ventricular Dysfunction, Right / blood*,  physiopathology,  surgery*
Young Adult
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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