Document Detail

Assessment of autonomic function in epileptic patients.
MedLine Citation:
PMID:  20956920     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To use spectral analysis to assess the autonomic activity of epileptic patients compared with normal patients, and to assess the clinical usefulness of the applied methods of signal processing.
METHODS: Forty-eight patients with generalized tonic-clonic seizures and who were not taking any medications, and 48 age and gender matched controls participated in this study from July to September 2007 at Johns Hopkins Hospital, Baltimore, Maryland, and the Medical Center, Cookeville, Tennessee, United States of America. All subjects consented to participate in the research prior to their inclusion in the study, and the local ethics committee approved the study protocol. The study design was to measure peripheral blood flow (PBF) and respiration signals as well as the heart rate variability (HRV) signals derived from the ECG during supine and standing positions.
RESULTS: The results clearly indicate that in patients with epilepsy, the coherence values are less than in the control group in both low frequency and high frequency bands at coherence spectra between HRV and PBF as well as HRV and respiration in both the supine and standing position.
CONCLUSION: Autopower and coherence spectra analysis for patients with epilepsy compared to normal subjects seems useful in the assessment of autonomic function for epileptic patients. Further studies are needed using other tests and methods of signal analysis.
Ahmed K Kamal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosciences (Riyadh, Saudi Arabia)     Volume:  15     ISSN:  1319-6138     ISO Abbreviation:  Neurosciences (Riyadh)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101252453     Medline TA:  Neurosciences (Riyadh)     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Department of MIT, Tennessee Tech University, PO Box 5003, Lewis Hall, Cookeville, TN 38505, United States of America. Tel. +1 (931) 2397570. Fax. +1 (931) 5261804. E-mail:
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