Document Detail

Assessment of aortic atheromatous plaque and stiffness by 64-slice computed tomography is useful for identifying patients with coronary artery disease.
MedLine Citation:
PMID:  18957788     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: With multislice computed tomography (MSCT) it is possible to visualize the coronary arteries, as well as the aorta, in a single computed tomography scan. Using MSCT, atherosis and sclerosis of the descending thoracic aorta (DTA) were quantified and differences between patients with and without coronary artery disease (CAD) were analyzed. METHODS AND RESULTS: The population comprised 89 patients who underwent ECG-gated MSCT: 40 patients with suspected CAD by MSCT underwent invasive coronary angiography, and had documented significant stenoses (CAD group), 49 patients did not have significant stenoses (control group). Twenty cross-sectional images of DTA were reconstructed every 5% (0-95%) of the RR interval, and the largest and smallest luminal areas were traced. Atheromatous score and stiffness beta of DTA were quantified; both were significantly higher in the CAD group than in the controls. Multivariate analysis revealed that the average atheromatous score was an independent factor associated with CAD (p<0.005). CONCLUSION: This study demonstrates that atherosis and sclerosis of DTA are associated with CAD. In cases with image quality that is unsatisfactory for interpretation of coronary stenoses, additional assessment of atherosclerosis of the DTA will be useful for identifying patients with CAD.
Takuhiro Okuyama; Shoichi Ehara; Nobuyuki Shirai; Kenichi Sugioka; Hajime Yamashita; Toru Kataoka; Takahiko Naruko; Toshihide Itoh; Katharina Otani; Toshiyuki Matsuoka; Yuichi Inoue; Makiko Ueda; Junichi Yoshikawa; Takeshi Hozumi; Minoru Yoshiyama
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Publication Detail:
Type:  Journal Article     Date:  2008-10-29
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2021-7     Citation Subset:  IM    
Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Aorta, Thoracic / radiography*
Aortic Diseases / complications,  radiography*
Aortography / methods*
Atherosclerosis / complications,  radiography*
Coronary Angiography / methods*
Coronary Stenosis / etiology,  radiography*
Middle Aged
Predictive Value of Tests
ROC Curve
Retrospective Studies
Risk Assessment
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Tomography, X-Ray Computed*

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