| Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. | |
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MedLine Citation:
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PMID: 19617657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare the indices of glutathione antioxidant system and oxidative damage level in resistance trained and untrained subjects and to assess the antioxidant action of alpha-lipoic acid in trained men exposed to muscle-damaging exercise. Thirteen trained and twenty untrained men (NT) participated in the comparative study. Then trained men were randomly assigned to T(CON) group (control) or T(ALA) group (alpha-lipoic acid, 600 mg . day(-1), for 8 days) and performed isometric/isokinetic effort of quadriceps muscles. The study has shown the significantly higher erythrocyte levels of glutathione (GSH), glutathione reductase (GR) and glutathione peroxidase (GPx) in T(CON) than NT but no differences in plasma lipid peroxidation (TBARS) and protein carbonylation (PC). However, total thiol (TT) concentration was two-fold lower in T(CON) than NT group. alpha-Lipoic acid variously influenced the post-exercise levels of GSH (+40%), GR (-24%) and GPx (+29%), but markedly reduced by over 30% the resting and post-exercise TBARS and PC in T(ALA) compared with T(CON). TT concentration significantly increased in T(ALA) but it did not reach the high level which was found in untrained group. It is concluded that alpha-lipoic acid supplementation diminishes oxidative damage. It does not abolish differences in glutathione antioxidant system between untrained and trained subjects but modulates a pro-antioxidant response to the muscle-damaging exercise. |
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Authors:
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A Zembron-Lacny; M Slowinska-Lisowska; Z Szygula; K Witkowski; T Stefaniak; W Dziubek |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 60 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 139-43 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Sports Medicine, University of Physical Education Poznan, Faculty of Physical Culture, Gorzow Wlkp., Poland. agzem@gorzow.home.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Antioxidants / pharmacology* Cross-Over Studies Double-Blind Method Erythrocytes / metabolism Exercise / physiology* Glutathione / blood Glutathione Peroxidase / metabolism Glutathione Reductase / metabolism Humans Isometric Contraction Lipid Peroxidation / drug effects Male Muscle, Skeletal / drug effects*, metabolism Oxidative Stress / drug effects* Protein Carbonylation / drug effects Thiobarbituric Acid Reactive Substances / metabolism Thioctic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; EC 1.11.1.9/Glutathione Peroxidase; EC 1.8.1.7/Glutathione Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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