Document Detail

Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise.
MedLine Citation:
PMID:  19617657     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to compare the indices of glutathione antioxidant system and oxidative damage level in resistance trained and untrained subjects and to assess the antioxidant action of alpha-lipoic acid in trained men exposed to muscle-damaging exercise. Thirteen trained and twenty untrained men (NT) participated in the comparative study. Then trained men were randomly assigned to T(CON) group (control) or T(ALA) group (alpha-lipoic acid, 600 mg . day(-1), for 8 days) and performed isometric/isokinetic effort of quadriceps muscles. The study has shown the significantly higher erythrocyte levels of glutathione (GSH), glutathione reductase (GR) and glutathione peroxidase (GPx) in T(CON) than NT but no differences in plasma lipid peroxidation (TBARS) and protein carbonylation (PC). However, total thiol (TT) concentration was two-fold lower in T(CON) than NT group. alpha-Lipoic acid variously influenced the post-exercise levels of GSH (+40%), GR (-24%) and GPx (+29%), but markedly reduced by over 30% the resting and post-exercise TBARS and PC in T(ALA) compared with T(CON). TT concentration significantly increased in T(ALA) but it did not reach the high level which was found in untrained group. It is concluded that alpha-lipoic acid supplementation diminishes oxidative damage. It does not abolish differences in glutathione antioxidant system between untrained and trained subjects but modulates a pro-antioxidant response to the muscle-damaging exercise.
A Zembron-Lacny; M Slowinska-Lisowska; Z Szygula; K Witkowski; T Stefaniak; W Dziubek
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  60     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Department of Biochemistry and Sports Medicine, University of Physical Education Poznan, Faculty of Physical Culture, Gorzow Wlkp., Poland.
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MeSH Terms
Administration, Oral
Antioxidants / pharmacology*
Cross-Over Studies
Double-Blind Method
Erythrocytes / metabolism
Exercise / physiology*
Glutathione / blood
Glutathione Peroxidase / metabolism
Glutathione Reductase / metabolism
Isometric Contraction
Lipid Peroxidation / drug effects
Muscle, Skeletal / drug effects*,  metabolism
Oxidative Stress / drug effects*
Protein Carbonylation / drug effects
Thiobarbituric Acid Reactive Substances / metabolism
Thioctic Acid / pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; EC Peroxidase; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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