Document Detail


Assessment of antibiotic resistance phenotype and integrons in Salmonella enterica serovar Typhimurium isolated from swine.
MedLine Citation:
PMID:  18981675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Salmonella enterica serovar Typhimurium (S. Typhimurium) isolated and identified from swine were subjected for the analysis of antibiotic resistance pattern and clinically important class 1 and 2 integrons. In addition, S. Typhimurium isolates exhibiting ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline and florfenicol (ACSSuTF) resistance pattern as described in most Salmonella enterica serotype Typhimurium definitive type 104 (DT104) were characterized by polymerase chain reaction. All the isolates were resistant to more than four antibiotics and showed the highest resistance to streptomycin (94.1%), followed by tetracycline (90.1%), ampicillin (64.7%), chloramphenicol (56.8%) and gentamicin (54.9%). MIC value for the ten isolates ranged between 0.125-2 mug/ml for ciprofloxacin. Among the beta-lactams used, only one of the isolate exhibited resistance to ceftiofur (MIC 8 microg/ml). Sixty eight percent of these multi drug resistance (MDR) S. Typhimurium isolates carried clinically important class 1 integron with 1kb (aadA) and/or 2kb (dhfrXII-orfF-aadA2) resistance gene cassettes. This study reports the increasing trend of multi drug resistance (MDR) S. Typhimurium with clinically important class 1 integron in pigs. In addition, emergence of the ACSSuTF-type resistance in S. Typhimurium PT other than DT104 may limit the use of resistance gene markers in its detection methods by PCR.
Authors:
Nabin Rayamajhi; Sang Gyun Kang; Mi Lan Kang; Hee Soo Lee; Kyung Yoon Park; Han Sang Yoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  70     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1133-7     Citation Subset:  IM    
Affiliation:
Department of Infectious Disease, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain Korea 21 for Veterinary Science, Seoul National University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteriophage Typing / veterinary
DNA, Bacterial / chemistry,  genetics
Drug Resistance, Multiple, Bacterial / genetics
Integrons / genetics
Korea / epidemiology
Microbial Sensitivity Tests / veterinary
Polymerase Chain Reaction / veterinary
Prevalence
Salmonella Infections, Animal / epidemiology,  microbiology*
Salmonella typhimurium / drug effects*,  genetics,  isolation & purification
Swine
Swine Diseases / epidemiology,  microbiology*
Chemical
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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