Document Detail


Assessment of angiotensin I metabolism in the human placenta using an LC/MS method.
MedLine Citation:
PMID:  24858328     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The local renin-angiotensin system (RAS) in the placenta plays a very important role in placental development. It is well known that during normal pregnancy most of the circulating and local RAS components are over-expressed and any disruption of this new balance may cause pregnancy complications. The aim of this study was to assess the metabolism of Ang I in placentas from normal pregnancy, in an ex vivo model, using an LC/MS method. The obtained results suggest that placental tissue is able to produce many angiotensin peptides but the main metabolite is Ang-(1-7).
Authors:
Dominika Stettner; Beata Bujak-Gizycka; Rafal Olszanecki; Krzysztof Rytlewski; Hubert Huras; Ryszard Korbut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia medica Cracoviensia     Volume:  53     ISSN:  0015-5616     ISO Abbreviation:  Folia Med Cracov     Publication Date:  2013  
Date Detail:
Created Date:  2014-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374617     Medline TA:  Folia Med Cracov     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
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