| Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography. | |
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MedLine Citation:
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PMID: 15886537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine age-related changes in left ventricular (LV) structure and function, the authors used freehand three-dimensional echocardiography, a previously validated tomographic technique, to measure LV mass, volumes, and derived parameters in 94 sedentary, but ambulatory and clinically healthy, adult male and female volunteers aged 20-94. LV volumes and mass were significantly greater in men than in women (p<0.001) and remained greater after adjustment for body surface area and height (p<0.05). Declines in end-diastolic and stroke volumes with age were reduced or absent after accounting for body size. By multivariate analysis, age accounted for only about 6%-11% of the variance among LV volumes and mass, in comparison with body surface area and gender, which accounted jointly for about 46%-77% of the variance. In conclusion, changes occur in LV structure and function with normal aging, but these changes are relatively minor when body size and gender are taken into account. |
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Authors:
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Michel G Khouri; Mathew S Maurer; Lyna El-Khoury Rumbarger |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of geriatric cardiology Volume: 14 ISSN: 1076-7460 ISO Abbreviation: Am J Geriatr Cardiol Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-05-11 Completed Date: 2005-10-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9215283 Medline TA: Am J Geriatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 118-25 Citation Subset: IM |
Affiliation:
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College of Physicians and Surgeons, Columbia University, New York, NY 11034, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Anthropometry Cross-Sectional Studies Echocardiography, Three-Dimensional* Female Heart Ventricles / ultrasonography* Humans Male Middle Aged Sex Factors Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG-00966/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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