Document Detail


Assessment of adenosine-induced coronary steal in the setting of coronary occlusion based on the extent of opacification defects by myocardial contrast echocardiography.
MedLine Citation:
PMID:  12934764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors examined the ability of real-time myocardial contrast echocardiography (MCE) to assess adenosine-induced coronary steal in the setting of coronary artery occlusion. The left anterior descending (LAD) coronary artery was occluded in 8 open-chest dogs. Real-time MCE was performed during LAD occlusion, and the extent of opacification defects from MCE was measured without and with adenosine infusion. Microsphere-derived myocardial blood flow (MBF) was measured in the LAD and left circumflex (LCx) coronary artery beds, and the LAD/LCx ratio of MBF was calculated. The LAD/LCx ratio of MBF decreased in response to adenosine administration (without adenosine: 0.66, with adenosine: 0.43, p < 0.01). The extent of opacification defects from MCE increased in response to adenosine administration (without adenosine: 18%, with adenosine: 22%, p < 0.01). Thus, real-time MCE allows for the detection of adenosine-induced coronary steal as changes in the extent of opacification defects in the setting of occlusion of 1 coronary artery accompanying another normally patent coronary artery.
Authors:
Hisashi Masugata; Barry Peters; Stephane Lafitte; G Monet Strachan; Koji Ohmori; Katsufumi Mizushige; Masakazu Kohno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  54     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-09-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-8     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Kagawa Medical University, 1750-1, Miki, Kita, Kagawa 761-0793, Japan. masugata@kms.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenosine / diagnostic use*
Animals
Arterial Occlusive Diseases / physiopathology,  ultrasonography*
Collateral Circulation
Coronary Circulation*
Coronary Disease / physiopathology,  ultrasonography*
Dogs
Echocardiography*
Chemical
Reg. No./Substance:
58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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