| Assessment of Tophus Size: A Comparison Between Physical Measurement Methods and Dual-Energy Computed Tomography Scanning. | |
| | |
MedLine Citation:
|
PMID: 22157268 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Dual-energy computed tomography (DECT) has recently been described as a sensitive method to detect urate deposits in patients with gout. OBJECTIVES: The aim of this study was to compare the reproducibility of DECT with various physical measurement methods of tophus size assessment. METHODS: Sixty-four tophi from 25 patients were analyzed. Each tophus was assessed by 2 independent observers using Vernier calipers and tape measure. All patients proceeded to DECT scanning of both feet. Urate volume within index tophi was assessed by 2 independent observers using automated DECT volume assessment software (n = 55 tophi). Five patients returned within 1 week for repeat physical assessment of tophus size. Dual-energy computed tomography scans from the returning patients were scored twice by both observers. Intraobserver and interobserver reproducibility was assessed by intraclass correlation coefficient (ICC) and limits-of-agreement analysis. RESULTS: Overall, DECT was more reproducible than the physical methods with interobserver ICCs for DECT of 0.95, for calipers 0.78, and for tape measurement 0.88, and intraobserver ICCs for DECT of 1.00, for calipers 0.75, and for tape measurement 0.91. Vernier caliper and tape measurements correlated highly with each other (rs = 0.84, P < 0.0001) but less well with DECT (for index tophi, rs = 0.46, P = 0.004 for both). Large variation was observed in the amount of urate deposits documented by DECT in tophi of similar physical size. CONCLUSIONS: Dual-energy computed tomography scanning is a highly reproducible method for measuring urate deposits within tophi. This imaging modality reveals the composition of tophi that contain variable urate deposits embedded within soft tissue. |
| | |
Authors:
|
Nicola Dalbeth; Opetaia Aati; Angela Gao; Meaghan House; Qiliang Liu; Anne Horne; Anthony Doyle; Fiona M McQueen |
Related Documents
:
|
15448998 - Distinguishing pelvic phleboliths from distal ureteral calculi: thin-slice ct findings. 22133288 - The clinical application of whole-body diffusion-weighted imaging in the early assessme... 1582818 - Accelerated gallstone dissolution in methyl tert-butyl ether by sonication. an in vitro... 21924408 - Bladder cancer: evaluation of staging accuracy using dynamic mri. 16242348 - A multivariate approach for processing magnetization effects in triggered event-related... 3956288 - Aortic root abscess. initial experience using magnetic resonance imaging. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
|
Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: - ISSN: 1536-7355 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the *Department of Medicine, University of Auckland; †Department of Radiology, Auckland District Health Board; and Departments of ‡Anatomy With Radiology, and §Molecular Medicine, University of Auckland, Auckland, New Zealand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Contrast-Enhanced Magnetic Resonance Imaging Positively Impacts the Management of Some Patients With...
Next Document: Eosinophilic Esophagitis and Pharyngitis Presenting as Mass Lesion in a Patient With Inactive Rheuma...