| Assessment of Toll-like receptor-4 gene polymorphism on pyelonephritis and renal scar. | |
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MedLine Citation:
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PMID: 22308961 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the effect of the TLR-4 gene TLR4 c.896A<G polymorphism on the development and clinical severity of urinary tract infections (UTI) and renal scar formations in children. The patients with first diagnosis of UTI (n = 112) and healthy controls (n = 93) were enrolled in the study. The TLR4 c.896A<G polymorphism was analysed in groups. The mean age of the patients in the study group was 8.1 ± 3.5 years and 9.2 ± 2.7 years for those in the control group. The TLR4 c.896A<G polymorphism was detected in 12.5% in the UTI group and in 15.1% of the control group. Forty patients showed pyelonephritis (PN) with scar tissue, 37 patients had PN without scars, and 35 patients had lower UTI. The TLR4 c.896A<G polymorphism was found in 22.5% of patients with scar-positive PN, and it was also present in 10.8% of patients with scar-negative PN and 2.9% of patients with lower UTI. We found higher TLR4 c.896A<G polymorphism and allelic frequency in patients with upper UTI compared to patients with lower UTI (P = 0.041 and P = 0.039, respectively). No significant difference was observed between patients and the control group for TLR-4 c.896A3. The TLR4 c.896A<G polymorphism and alleles were higher in patients with upper UTI than in patients with lower UTI. The TLR4 c.896A<G polymorphism frequency was nearly twice that in the scar-positive PN patients when compared to the scar-negative patients. Larger-scale studies involving larger numbers of patients should be performed. |
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Authors:
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I Akil; F Ozkinay; H Onay; E Canda; G Gumuser; S Kavukcu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: International journal of immunogenetics Volume: - ISSN: 1744-313X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101232337 Medline TA: Int J Immunogenet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Pediatric Nephrology, Celal Bayar University, Izmir, Turkey Department of Medical Genetics and Pediatric Infectious Diseases, Ege University, Izmir, Turkey Department of Medical Genetics, Ege University, Izmir, Turkey Department of Pediatrics, Celal Bayar University, Izmir, Turkey Department of Nuclear Medicine, Celal Bayar University, Izmir, Turkey Department of Pediatric Nephrology, Dokuz Eylul University, Izmir, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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