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An Assessment of the Severity of Interstitial Pancreatitis.
MedLine Citation:
PMID:  21893128     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND & AIMS: There is limited information on the incidence of and factors associated with severe disease among patients with interstitial pancreatitis (IP). We evaluated a large cohort of patients with IP and compared data with those from patients with extrapancreatic necrosis (EXPN). METHODS: We evaluated 149 consecutive patients with IP admitted over a 2.5 year period. Transferred patients were excluded. We ecollected data on age, Charlson comorbidity score (CCI), measures of severity on admission or within ≤24 hrs. (APACHE II, BISAP scores), persistent (>48 hrs.) systemic inflammatory response syndrome, persistent organ failure, need for ICU, length of hospital stay (in days), and mortality. We also analyzed levels of severity among those with IP and EXPN. Statistical analysis was performed using SAS v. 9.1. RESULTS: Among the patients with IP, the median CCI score was 1, the median APACHE II score 7, and the median BISAP score 1. In addition, the median length of hospital stay was only 4 days; only 1% had persistent organ failure and only 1-2% required intervention. The mortality of IP was 3%; it was significantly associated with comorbidity (the median CCI scores of nonsurvivors and survivors was 4 and 1, respectively, P=0.003). Patients with EXPN had greater levels of disease severity, compared to patients with IP. CONCLUSIONS: IP is severe in only 1-3% of patients; mortality of IP is strongly associated with comorbidity. EXPN is more frequently severe than IP; EXPN must be distinguished from IP in clinical studies.
Authors:
Vikesh K Singh; Thomas L Bollen; Bechien U Wu; Kathryn Repas; Rie Maurer; Song Yu; Koenraad J Mortele; Darwin L Conwell; Peter A Banks
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-2
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  -     ISSN:  1542-7714     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Affiliation:
Division of Gastroenterology, Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School.
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