Document Detail

Assessment of residual viability by enoximone echocardiography in patients with previous myocardial infarction correlation with positron emission tomographic studies and functional follow-up.
MedLine Citation:
PMID:  20374267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate enoximone echocardiography (EE) for the identification of residual myocardial viability in postinfarction patients. Findings obtained during EE were compared with those acquired by myocardial uptake of fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) and functional follow-up results. METHODS: Twenty-five patients underwent EE and PET (18)F-FDG studies. An asynergic segment was considered as having contractile enhancement when the wall motion score decreased by > or = 1 grade during EE and was defined as viable if (18)F-FDG uptake score was > or = 2 grade on PET. RESULTS: Of 293 dysfunctional segments at baseline, 139 (47%) were viable by PET criteria; 117 (40%) had contractile enhancement induced by enoximone (P = 0.07). Agreement between EE and PET was found in 75% of involved segments (K = 0.46, P < 0.001). The majority of discrepancies (65%, P < 0.01) were mainly due to discordant segments in which PET revealed evidence of (18)F-FDG uptake but EE showed no change in wall motion. In 179 revascularized segments, negative predictive value for functional recovery of both tests reached the same value (89% for both), whereas positive predictive value was 82% for EE and 68% for PET, respectively (P < 0.05). Sensitivity was 85% for EE and 88% for PET (P = ns); specificity was 87% and 70%, respectively (P < 0.01). CONCLUSIONS: EE yields a fair concordance with PET study. Compared with PET, despite a similar negative accuracy, EE shows a greater specificity for prediction of function recovery after revascularization. (Echocardiography 2010;27:544-551).
Fei Lu; Mauro Carlino; Chunzeng Lu; Claudio Landoni; Giovanni Lucignani; Gabriele Fragasso; Vitantonio Di Bello; Alberto Margonato; Sergio L Chierchia; Mario Marzilli; Alberto Balbarini
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Publication Detail:
Type:  Journal Article     Date:  2010-03-30
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  27     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-51     Citation Subset:  IM    
Division of Cardiovascular Medicine, Cardiothoracic Department, University of Pisa, Pisa, Italy.
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MeSH Terms
Coronary Angiography
Echocardiography / methods*
Enoximone / diagnostic use*
Fluorodeoxyglucose F18 / diagnostic use
Image Interpretation, Computer-Assisted
Middle Aged
Myocardial Contraction
Myocardial Infarction / physiopathology*,  radionuclide imaging,  ultrasonography*
Myocardial Revascularization
Positron-Emission Tomography
Predictive Value of Tests
Radiopharmaceuticals / diagnostic use
Vasodilator Agents / diagnostic use*
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Vasodilator Agents; 63503-12-8/Fluorodeoxyglucose F18; 77671-31-9/Enoximone

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