Document Detail

Assessment of pre-diagnosis biomarkers of immune activation and inflammation: insights on the etiology of lymphoma.
MedLine Citation:
PMID:  20886858     Owner:  NLM     Status:  MEDLINE    
The DNA-modifying processes that are involved in B lymphocyte activation, somatic hypermutation (SHM), and IgH class switch recombination (CSR) have the potential to lead to genetic errors that lead to the genesis of B cell cancers, such as lymphoma. Given the potential contribution of these immune mechanisms to the development of cancer, assessment of the expression of cytokines, and other immune stimulatory molecules that drive B cell activation, prior to lymphoma diagnosis, may provide insights into the etiology of these cancers. Here, we review studies that have examined prediagnosis protein biomarkers for non-Hodgkin lymphoma (NHL), both AIDS-related NHL, as well as NHL seen in immunocompetent populations. Overall, these studies provide support for the notion that B cell hyper-activation is elevated preceding the appearance of AIDS-NHL, particularly those forms of AIDS-NHL that are not driven by EBV infection and that presumably arise from errors in IgH CSR and SHM. In more limited studies, it appears that dysregulation of cytokine production also precedes the diagnosis of NHL in HIV-negative persons. The availability of prediagnosis serum/plasma from cohort studies provides unique opportunities for proteomic approaches to identify novel prediagnosis etiologic biomarkers for NHL.
Elena Vendrame; Otoniel Martínez-Maza
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-01
Journal Detail:
Title:  Journal of proteome research     Volume:  10     ISSN:  1535-3907     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-07     Completed Date:  2011-05-16     Revised Date:  2013-11-08    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Departments of Obstetrics & Gynecology and Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, California, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications
Biological Markers*
Lymphoma, Non-Hodgkin* / complications,  diagnosis,  immunology
Grant Support
AI35040/AI/NIAID NIH HHS; CA121195/CA/NCI NIH HHS; CA121947/CA/NCI NIH HHS; CA57152/CA/NCI NIH HHS; R01 CA057152/CA/NCI NIH HHS; R01 CA057152-15/CA/NCI NIH HHS; R01 CA121195/CA/NCI NIH HHS; R01 CA121195-04/CA/NCI NIH HHS; U01 AI035040-19/AI/NIAID NIH HHS; U01 CA121947/CA/NCI NIH HHS; U01 CA121947-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers

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