| Assessment of pharmacotherapy for negative symptoms of schizophrenia. | |
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MedLine Citation:
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PMID: 20821286 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Negative symptoms in schizophrenia include diminished ability to communicate, motivate, and socialize as potentially debilitating aspects of the illness that are associated with long-term impairment. Despite such burden, the domain has been underrepresented in drug development and treatment research. In this article, we review research regarding pharmacotherapy for negative symptoms, with a focus on studies published during the past 2 years. Clearly positive studies were limited to N-methyl-D-aspartate agonists, while antipsychotics and antidepressants did not show substantial benefit, and cognitive enhancers have yielded mixed results. Proof-of-concept studies of other agents such as minocycline and omega fatty acids yielded promising, albeit preliminary findings that warrant replication. Study outcomes and designs are discussed along with implications for future research. |
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Authors:
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Elizabeth Hanson; Kristin Healey; Daniel Wolf; Christian Kohler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current psychiatry reports Volume: 12 ISSN: 1535-1645 ISO Abbreviation: Curr Psychiatry Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888960 Medline TA: Curr Psychiatry Rep Country: United States |
Other Details:
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Languages: eng Pagination: 563-71 Citation Subset: IM |
Affiliation:
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Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, 19104, USA. elizabgh@upenn.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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