| Assessment of the P-glycoprotein expression by 99mTc-MIBI bone marrow imaging in patients with untreated leukaemia. | |
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MedLine Citation:
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PMID: 12673168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of cancer cells to become simultaneously resistant to different drugs is a significant impediment to successful chemotherapy. 99mTc-MIBI has been reported to be a transport substrate for P-glycoprotein (Pgp). The aim of the study was to ascertain the relationship between the degree of 99mTc-MIBI uptake and the level of Pgp expression in patients with newly diagnosed leukaemia. A total of 26 patients (12 female and 14 male; mean age 46.8+/-3.7 years) with newly diagnosed leukaemia were included in the study. None of the patients had been previously treated with chemotherapy. Images were obtained 20 min post-injection of 740 MBq 99mTc-MIBI. Whole-body and planar spot images of the pelvis and thorax were acquired. The uptake of the MIBI in the bone marrow was evaluated using a qualitative and also a quantitative scoring system with determination of the tumour-to-background (T/B) ratios. Flow cytometry was performed for determining the Pgp expression of the blast cells in the bone marrow aspiration samples. There was a statistically significant inverse relationship between the Pgp level in numeric values and both mean qualitative (P<0.001; r=-0.665) and quantitative (P=0.001; r=-0.606) results of 99mTc-MIBI imaging. Both the mean qualitative score and the T/B ratios were higher in patients who were Pgp negative than in those who were Pgp positive (P<0.001 and P<0.001, respectively). These data indicate that an increased level of Pgp expression is correlated with a low accumulation of 99mTc-MIBI in bone marrow of patients with leukaemia. 99mTc-MIBI bone marrow imaging, as a method of functional imaging, can give in vivo information concerning the functional expression of the MDR phenotype in patients with untreated leukaemia. |
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Authors:
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I Ak; V Aslan; E Vardareli; Z Gülbaş |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Validation Studies |
Journal Detail:
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Title: Nuclear medicine communications Volume: 24 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-03 Completed Date: 2004-02-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 397-402 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Osmangazi University Medical Faculty, Eskişehir, Turkey. ilknur_ak@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Marrow / metabolism*, radionuclide imaging* Drug Resistance, Multiple Female Humans Leukemia / metabolism*, radionuclide imaging* Leukemia, Myeloid, Acute / metabolism, radionuclide imaging Male Middle Aged P-Glycoprotein / metabolism* Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism, radionuclide imaging Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity Statistics as Topic Technetium Tc 99m Sestamibi / diagnostic use*, pharmacokinetics* Tissue Distribution Whole-Body Counting / methods |
| Chemical | |
Reg. No./Substance:
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0/P-Glycoprotein; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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