| Assessment of lung inflammation with 18F-FDG PET during acute lung injury. | |
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MedLine Citation:
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PMID: 20651183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this review is to describe the current experimental and clinical data regarding the fundamentals and applications of (18)F-FDG PET during acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). CONCLUSION: Lung inflammation is a key feature of ALI. During ALI, FDG PET can be used to monitor lung neutrophils, which are essential cells in the pathophysiologic mechanisms of ALI. Pulmonary FDG kinetics are altered during experimental and human ALI and are associated with regional lung dysfunction, histologic abnormalities, and prognosis. FDG PET may be a valuable noninvasive method for gaining comprehensive understanding of the mechanisms of ALI/ARDS and for evaluating therapeutic interventions. |
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Authors:
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Nicolas de Prost; Mauro R Tucci; Marcos F Vidal Melo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 195 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-09-24 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 292-300 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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radionuclide imaging* Fluorodeoxyglucose F18 / diagnostic use* Humans Pneumonia / radionuclide imaging* Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use* Respiratory Distress Syndrome, Adult / radionuclide imaging* |
| Grant Support | |
ID/Acronym/Agency:
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HL 5R01HL086827/HL/NHLBI NIH HHS; R01 HL086827-04/HL/NHLBI NIH HHS; R01 HL086827-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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