Document Detail


Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
MedLine Citation:
PMID:  19581812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In recent years noninvasive methods have been evaluated for the assessment of liver fibrosis predominantly in patients with viral hepatitis. In this study, transient elastography (FibroScan), magnetic resonance imaging (MRI), magnetic resonance (MR)-spectroscopy, and serum markers were compared in patients with primary biliary cirrhosis (PBC) for the assessment of liver fibrosis and steatosis. METHODS: Forty-five patients with PBC and histologic assessment of liver fibrosis received transient elastography and examinations for serum markers of fibrosis and steatosis. In addition, 41 out of 45 patients received contrast-enhanced MRI and 38 out of 45 patients received proton MR-spectroscopy. RESULTS: The adjusted accuracy (area under the receiver operating characteristic) for the diagnosis of histologic-stage > or = II for FibroScan, MRI-contrast enhancement and Forns index was 80%, 83%, and 69%, and for the diagnosis of liver cirrhosis 95%, 91%, and 94%, respectively. No correlation of histologic-stage was observed for FibroTest and AST to platelet ratio index. Histologic steatosis significantly correlated with body mass index (r=0.46), the SteatoTest (r=0.39), homeostasis model assessment of insulin resistance (r=0.46), and MR-spectroscopy (r=-0.76). The accuracy for the diagnosis of histologic steatosis was best with MR-spectroscopy (88%). CONCLUSIONS: Contrast-enhanced MRI and FibroScan can be used with comparable results for the assessment of liver fibrosis in patients with PBC and seem to supplement each other. MR-spectroscopy represents the best method for highly accurate noninvasive measurement of liver steatosis.
Authors:
Mireen Friedrich-Rust; Cindy M?ller; Anne Winckler; Susanne Kriener; Eva Herrmann; Julia Holtmeier; Thierry Poynard; Thomas J Vogl; Stefan Zeuzem; Renate Hammerstingl; Christoph Sarrazin
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  44     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-22     Completed Date:  2010-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine 1, J.W. Goethe-University, Frankfurt, Germany. Mireen Friedrich-Rust@kgu.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Body Mass Index
Disease Progression
Elasticity Imaging Techniques / methods*
Fatty Liver / diagnosis,  pathology
Female
Homeostasis
Humans
Insulin Resistance
Liver Cirrhosis, Biliary / diagnosis*,  pathology
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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