Document Detail

Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri.
MedLine Citation:
PMID:  22231455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently much attention has been paid to biologically active plants because of their low production cost and fewer adverse effects compared with chemical drugs. In the present investigation the bioactivity of Phyllanthus niruri ethanol and aqueous extracts was evaluated in vitro.
RESULTS: The ethanol extract of P. niruri showed a high level of flavonoid content (123.9 ± 0.002 mg g⁻¹), while the aqueous extract showed the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC₅₀ 6.85 ± 1.80 µmol L⁻¹) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS; 46.44 ± 0.53 µmol L⁻¹) free radical scavenging activities with high phenol content (376 ± 0.02 mg g⁻¹) and elevated levels of ferric reducing antioxidant power (FRAP; 23 883 ± 0.019 mmol g⁻¹) with excellent antibacterial activity against Staphylococcus aureus (20 mm inhibition zone) and Streptococcus agalactiae (12 mm inhibition zone), respectively, in addition to the best immune activation potential of human peripheral blood mononuclear cells (450.5%).
CONCLUSIONS: It is clear from our results that both extracts of P. niruri has excellent bioactivity roles via elevated levels of antibacterial, antioxidant and percentage of peripheral blood mononuclear cell proliferation, which could lead to the development of medications for clinical use.
Zahra A Amin; Mahmood A Abdulla; Hapipah M Ali; Mohammed A Alshawsh; Suhailah W Qadir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-09
Journal Detail:
Title:  Journal of the science of food and agriculture     Volume:  92     ISSN:  1097-0010     ISO Abbreviation:  J. Sci. Food Agric.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-07     Completed Date:  2012-10-09     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  0376334     Medline TA:  J Sci Food Agric     Country:  England    
Other Details:
Languages:  eng     Pagination:  1874-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Society of Chemical Industry.
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Anti-Bacterial Agents / pharmacology*
Antioxidants / pharmacology*
Bacteria / drug effects*
Biphenyl Compounds / metabolism
Cell Proliferation / drug effects
Leukocytes, Mononuclear / drug effects*,  immunology
Phyllanthus / chemistry*
Picrates / metabolism
Plant Extracts / pharmacology*
Staphylococcus aureus / drug effects
Streptococcus agalactiae / drug effects
Sulfonic Acids / metabolism
Thiazoles / metabolism
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Bacterial Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Picrates; 0/Plant Extracts; 0/Sulfonic Acids; 0/Thiazoles; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 28752-68-3/2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid

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