| Assessment of HbA1c as a diagnostic tool in diabetes and prediabetes. | |
| | |
MedLine Citation:
|
PMID: 21964885 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To evaluate HbA1c as a diagnostic tool in prediabetes-impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and newly detected diabetes (NDD), defined by plasma glucose and OGTT. 2,231 subjects, of mean age 50.3 ± 13.9 years and mean BMI 29.5 ± 6.2 kg/m(2), underwent an OGTT. HbA1c performance was assessed using the area under the receiver operating characteristics curve (AUC-ROC). HbA1c was significantly higher in all groups with altered glucose tolerance-5.72 ± 0.61% in IFG, 5.84 ± 0.63% in IGT, and 7.5 ± 1.69% in NDD when compared to normal glucose tolerance-5.23 ± 0.65% (P < 0.0001). HbA1c of both prediabetic groups was significantly lower in comparison with NDD (P < 0.0001); in IGT being significantly higher than in IFG (P = 0.02). ROC analysis demonstrated good performance of HbA1c for diagnosing diabetes-AUC-ROC 0.958 (95% CI: 0.946-0.970), as well as prediabetes-AUC-ROC 0.729 (95% CI: 0.702-0.755). The optimal cut-off level of HbA1c for diagnosing diabetes was 6.1% (sensitivity 86%, specificity 92%) and for undiagnosed prediabetes-5.5% (sensitivity 71%, specificity 64%). HbA(1c) appears to be a useful, convenient, and reliable tool for identifying subjects with prediabetes and diabetes and should be considered in the development of diagnostic strategies. |
| | |
Authors:
|
Tsvetalina Tankova; Nevena Chakarova; Lilia Dakovska; Iliana Atanassova |
Related Documents
:
|
2513375 - Influence of iron-limited and replete continuous culture on the physiology and virulenc... 21167705 - Nano nickel oxide modified non-enzymatic glucose sensors with enhanced sensitivity thro... 7608825 - Vitamin e in plasma and milk of lactating women with insulin-dependent diabetes mellitus. 22415875 - Calorie restriction reduces the influence of glucoregulatory dysfunction on regional br... 17446535 - Mutations in atp-sensitive k+ channel genes cause transient neonatal diabetes and perma... 8560405 - Influence of various heparin preparations on lipoproteins in hemodialysis patients: a m... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-2 |
Journal Detail:
|
Title: Acta diabetologica Volume: - ISSN: 1432-5233 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Diabetology, Clinical Centre of Endocrinology, University Hospital of Endocrinology, Medical University, 2, Zdrave str., 1431, Sofia, Bulgaria, tankova@iname.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gut microbiota and diabetes: from pathogenesis to therapeutic perspective.
Next Document: Voltammetric determination of glutathione in haemolysed erythrocyte and tablet samples using modifie...