| Assessment of the Frank-Starling relationship by two-dimensional echocardiography. | |
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MedLine Citation:
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PMID: 8736005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements. |
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Authors:
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D A Zipprich; C H Owen; C W Lewis; S A Gall; J W Davis; J A Kisslo; D D Glower |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 9 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 1996 May-Jun |
Date Detail:
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Created Date: 1996-11-07 Completed Date: 1996-11-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-40 Citation Subset: IM |
Affiliation:
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Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Blood Volume / drug effects, physiology Calcium Chloride / administration & dosage Cardiac Volume / drug effects, physiology Diastole / drug effects, physiology* Dogs Echocardiography / instrumentation* Fourier Analysis Humans Image Processing, Computer-Assisted* Models, Cardiovascular Nitroprusside / administration & dosage Papillary Muscles / drug effects, physiology, ultrasonography Phenylephrine / administration & dosage Stroke Volume / drug effects, physiology* Systole / drug effects, physiology Ventricular Function, Left / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL09315/HL/NHLBI NIH HHS; HL17670/HL/NHLBI NIH HHS; HL46242/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10043-52-4/Calcium Chloride; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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