Document Detail

Assessment of the Frank-Starling relationship by two-dimensional echocardiography.
MedLine Citation:
PMID:  8736005     Owner:  NLM     Status:  MEDLINE    
The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements.
D A Zipprich; C H Owen; C W Lewis; S A Gall; J W Davis; J A Kisslo; D D Glower
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  9     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-40     Citation Subset:  IM    
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Blood Volume / drug effects,  physiology
Calcium Chloride / administration & dosage
Cardiac Volume / drug effects,  physiology
Diastole / drug effects,  physiology*
Echocardiography / instrumentation*
Fourier Analysis
Image Processing, Computer-Assisted*
Models, Cardiovascular
Nitroprusside / administration & dosage
Papillary Muscles / drug effects,  physiology,  ultrasonography
Phenylephrine / administration & dosage
Stroke Volume / drug effects,  physiology*
Systole / drug effects,  physiology
Ventricular Function, Left / drug effects,  physiology*
Grant Support
Reg. No./Substance:
10043-52-4/Calcium Chloride; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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