Document Detail

Assessment of Epstein-Barr virus in blood from patients with multiple sclerosis.
MedLine Citation:
PMID:  22407028     Owner:  NLM     Status:  Publisher    
Viruses such as Epstein-Barr virus (EBV) which can establish latent infections in the central nervous system or the immune system have been associated with chronic neurological disorders, including multiple sclerosis. Results vary, therefore the aim of this study was to investigate the presence of EBV using both viral DNA and antibody screening techniques, using PCR and ELISA assays respectively, to evaluate viral presence in blood from control subjects and patients with multiple sclerosis. Viral gene sequences for latent proteins EBNA-1 and LMP-1 and lytic gene BamH1-W were present equally in both patients and controls (<7%). Anti-EBV-VCA IgG positive cases were present in >99% of all study subjects, and anti-EBV-VCA IgG immune status ratio showed a near-significant positive correlation with the EDSS in patients with multiple sclerosis. In contrast, Anti-EBV-VCA IgM positive cases were significantly increased in patients (controls: 23.3%; patients; 41.9%; P = 0.046). The IgM to IgG immune status ratio was near-significantly higher in patients with relapse episodes in the year preceding blood sampling (P = 0.058). Results from this and previous studies have shown higher prevalence rates for EBV evaluating anti-EBV IgM positive cases against viral DNA positive cases. Also, IgM, an innate immune response, showed an association with relapse episodes, suggesting viral re-activation as a contributing factor to these relapses.
Gloudina M Hon; Mogamat S Hassan; Susan J van Rensburg; Rajiv T Erasmus; Tandi E Matsha
Related Documents :
1792968 - A series of experimental surgery for advanced parkinson's disease by foetal mesencephal...
12373528 - Recognition and treatment of response fluctuations in parkinson's disease: review article.
7682308 - Concentrations of serotonin and its related substances in the cerebrospinal fluid of pa...
11673328 - The gait disorder of advanced essential tremor.
6206028 - Globin synthetic ratios in homozygous beta-thalassemia patients from lebanon.
20368218 - Elastic properties and structure of the radial artery in patients with type 2 diabetes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-10
Journal Detail:
Title:  Metabolic brain disease     Volume:  -     ISSN:  1573-7365     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Belliville Campus, 7530, Cape Town, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adaptive evolution of loci covarying with the human African Pygmy phenotype.
Next Document:  P53 and the proteasome regulate androgen receptor activity.