Document Detail

Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging.
MedLine Citation:
PMID:  22710483     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with myotonic muscular dystrophy (DM) are at risk for atrioventricular block and left ventricular (LV) dysfunction. Noninvasive detection of diffuse myocardial fibrosis may improve disease management in this population.
OBJECTIVE: To define functional and postcontrast myocardial T1 time cardiac magnetic resonance characteristics in patients with DM.
METHODS: Thirty-three patients with DM (24 with type 1 and 9 with type 2) and 13 healthy volunteers underwent cardiac magnetic resonance for the assessment of LV indices and the evaluation of diffuse myocardial fibrosis by T1 mapping. The association of myocardial T1 time with electrocardiogram abnormalities and LV indices was examined among patients with DM.
RESULTS: Patients with DM had lower end-diastolic volume index (68.9 mL/m(2) vs 60.3 mL/m(2); P = .045) and cardiac index (2.7 L/min/m(2) vs 2.33 L/min/m(2); P = .005) and shorter myocardial T1 time (394.5 ms vs 441.4 ms; P < .0001) than did control subjects. Among patients with DM, there was a positive association between higher T1 time and LV mass index (2.2 ms longer per g/m(2); P = .006), LV end-diastolic volume index (1.3 ms longer per mL/m(2); P = .026), filtered QRS duration (1.2 ms longer per unit; P = .005), and low-amplitude (<40 mcV) late-potential duration (0.9 ms longer per unit; P = .01). Using multivariate random effects regression, each 10-ms increase in myocardial T1 time of patients with type 1 DM was independently associated with 1.3-ms increase in longitudinal PR and QRS intervals during follow-up.
CONCLUSIONS: DM is associated with structural alterations on cardiac magnetic resonance. Postcontrast myocardial T1 time was shorter in patients with DM than in controls, likely reflecting the presence of diffuse myocardial fibrosis.
Evrim B Turkbey; Neville Gai; João A C Lima; Rob J van der Geest; Kathryn R Wagner; Gordon F Tomaselli; David A Bluemke; Saman Nazarian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-16
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  9     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-26     Completed Date:  2013-05-27     Revised Date:  2014-01-14    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1691-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Heart Rhythm Society. All rights reserved.
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MeSH Terms
Cardiomyopathies / pathology*
Case-Control Studies
Contrast Media / diagnostic use
Disease Progression
Gadolinium DTPA / diagnostic use
Magnetic Resonance Imaging, Cine / methods*
Middle Aged
Myotonic Dystrophy / pathology*
Risk Factors
Grant Support
Reg. No./Substance:
0/Contrast Media; K2I13DR72L/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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