| Assessment of CA-125 area under the curve as a prognostic factor in patients with ovarian cancer. | |
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MedLine Citation:
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PMID: 23322523 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The goal of this study was to evaluate the efficacy of CA-125 area under the curve (CA-125 AUC) as a prognostic factor following surgical treatment for ovarian cancer patients. A retrospective analysis was conducted on ninety-five patients with ovarian cancer who had primary treatment in a tertiary center between 2000 and 2010. After either optimal or cytoreductive surgery, all patients underwent adjuvant chemotherapy. CA-125 AUC was calculated for each patient that had a minimum of three CA-125 serum measurements during the treatment period. The mean age at diagnosis and mean survival were 53.9 years (range, 16-75 years) and 35.6 ± 22.9 months (range, 3.1-95.4 months), respectively. The mean (and median) CA-125 AUC of patients of FIGO stages I, II, III, and IV was 53.0 (42.5), 58.06 (58.06), 97.8 (54.6), and 405.2 (149.3) IU/ml day, respectively (p = 0.004). The mean CA-125 AUC was 57.7, 410.1, and 636.3 IU/ml day for patients with a complete response, partial response, and no response/progressive disease to first-line chemotherapy, respectively (p < 0.001). The CA-125 AUC cut-off level for an overall survival of ≥5 years was 99.75 IU/ml day with a sensitivity of 90.9 % (95 % CI, 70.8-98.6) with 1.27 as positive likelihood ratio. Patients who suffer from ovarian cancer, with a lower CA125 AUC, have a better overall survival than those with a higher CA125 AUC. CA-125 AUC could be used as an independent factor for evaluating the treatment efficacy and chemotherapy response. |
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Authors:
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Sernaz Uzunoglu; Aysun Aybatlı; Petek Balkanlı Kaplan; Irfan Cicin; Necdet Sut; Cenk Sayın; Fusun Varol |
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Publication Detail:
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Type: Journal Article Date: 2013-01-16 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 30 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 447 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Trakya University Faculty of Medicine, 22030, Edirne, Turkey, sernaz.uzunoglu@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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