Document Detail

Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
MedLine Citation:
PMID:  18458229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity. METHODS: A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (Class I-IV). RESULTS: The highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies). RECOMMENDATIONS: Botulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).
D M Simpson; J-M Gracies; H K Graham; J M Miyasaki; M Naumann; B Russman; L L Simpson; Y So;
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Neurology     Volume:  70     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-06     Completed Date:  2008-06-06     Revised Date:  2009-10-13    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1691-8     Citation Subset:  AIM; IM    
Department of Neurology, Mount Sinai Medical Center, New York, NY, USA.
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MeSH Terms
Age Factors
Botulinum Toxins / administration & dosage*
Clinical Trials as Topic / statistics & numerical data
Dose-Response Relationship, Drug
Evidence-Based Medicine / methods
Muscle Spasticity / drug therapy*,  etiology,  physiopathology
Muscle, Skeletal / drug effects*,  innervation,  physiopathology
Neuromuscular Blocking Agents / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Botulinum Toxins; 0/Neuromuscular Blocking Agents
Comment In:
Neurology. 2009 Sep 1;73(9):736; author reply 737-8   [PMID:  19720984 ]

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