| Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York City. | |
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MedLine Citation:
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PMID: 20622999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5-6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (Sigma(8)PAH; MW >or= 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ)(Sigma8PAH) and (BaP-MEQ)(Sigma8PAH) both indoors and outdoors (p < 0.001). Outdoor (BaP-TEQ)(Sigma8)(PAH) and (BaP-MEQ)(Sigma8PAH) were significantly higher than the corresponding indoor measures during the heating season (p < 0.01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation. |
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Authors:
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Kyung Hwa Jung; Beizhan Yan; Steven N Chillrud; Frederica P Perera; Robin Whyatt; David Camann; Patrick L Kinney; Rachel L Miller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: International journal of environmental research and public health Volume: 7 ISSN: 1660-4601 ISO Abbreviation: Int J Environ Res Public Health Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-05 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 101238455 Medline TA: Int J Environ Res Public Health Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1889-900 Citation Subset: IM |
Affiliation:
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Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, New York, NY 10032, USA. kj2237@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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toxicity* Air Pollution, Indoor Benzo(a)pyrene / toxicity* Carcinogenicity Tests Child Child, Preschool Environmental Exposure* Environmental Monitoring Humans Mutagenicity Tests New York City Polycyclic Compounds / toxicity* Quality Control Seasons |
| Grant Support | |
ID/Acronym/Agency:
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P01 ES009600/ES/NIEHS NIH HHS; P01ES09600/ES/NIEHS NIH HHS; P50ES015905/ES/NIEHS NIH HHS; R01 ES008977-14/ES/NIEHS NIH HHS; R01 ES013163/ES/NIEHS NIH HHS; R01 ES013163-04/ES/NIEHS NIH HHS; R01 ES013163-05/ES/NIEHS NIH HHS; R01ES013163/ES/NIEHS NIH HHS; R01ES08977/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Polycyclic Compounds; 50-32-8/Benzo(a)pyrene |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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