Document Detail


Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York City.
MedLine Citation:
PMID:  20622999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5-6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (Sigma(8)PAH; MW >or= 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ)(Sigma8PAH) and (BaP-MEQ)(Sigma8PAH) both indoors and outdoors (p < 0.001). Outdoor (BaP-TEQ)(Sigma8)(PAH) and (BaP-MEQ)(Sigma8PAH) were significantly higher than the corresponding indoor measures during the heating season (p < 0.01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation.
Authors:
Kyung Hwa Jung; Beizhan Yan; Steven N Chillrud; Frederica P Perera; Robin Whyatt; David Camann; Patrick L Kinney; Rachel L Miller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-04-27
Journal Detail:
Title:  International journal of environmental research and public health     Volume:  7     ISSN:  1660-4601     ISO Abbreviation:  Int J Environ Res Public Health     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-05     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  101238455     Medline TA:  Int J Environ Res Public Health     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1889-900     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / toxicity*
Air Pollution, Indoor
Benzo(a)pyrene / toxicity*
Carcinogenicity Tests
Child
Child, Preschool
Environmental Exposure*
Environmental Monitoring
Humans
Mutagenicity Tests
New York City
Polycyclic Compounds / toxicity*
Quality Control
Seasons
Grant Support
ID/Acronym/Agency:
P01 ES009600/ES/NIEHS NIH HHS; P01ES09600/ES/NIEHS NIH HHS; P50ES015905/ES/NIEHS NIH HHS; R01 ES008977/ES/NIEHS NIH HHS; R01 ES013163/ES/NIEHS NIH HHS; R01 ES013163-04/ES/NIEHS NIH HHS; R01ES013163/ES/NIEHS NIH HHS; R01ES08977/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Polycyclic Compounds; 3417WMA06D/Benzo(a)pyrene
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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