Document Detail

Assessment of atrial conduction abnormalities in patients with hypertrophic cardiomyopathy before and one year after alcohol septal ablation.
MedLine Citation:
PMID:  23235112     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Intra- and interatrial electromechanical delay (AEMD) can be used to evaluate the development of atrial fibrillation (AF). Percutaneous transluminal septal myocardial ablation (PTSMA) is an alternative therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM) that results in sustained improvements in atrial structure and function. We investigated the effects of PTSMA on the intra- and inter-AEMD of HOCM patients using tissue Doppler imaging.
METHODS: Conventional echocardiographic and AEMD parameters were obtained in 25 healthy controls and 31 HOCM patients before and 1 year after septal ablation procedures.
RESULTS: Compared with the healthy controls, the left atrial volumes indexed by body surface area (LAVI) and the intra- and inter-AEMD were significantly higher in the HOCM patients. At 1 year after PTSMA, the LAVI was decreased (37.2 ± 11.4 to 27.0 ± 8.5 ml/m(2), p < 0.001). The intra- and inter-AEMD were also significantly decreased (22.7 ± 9.2 to 16.6 ± 7.7 ms, p < 0.001 and 37.0 ± 8.4 to 26.6 ± 8.0 ms, p < 0.001, respectively). These changes correlated well with the reductions in LAVI (r = 0.83, p < 0.001; r = 0.66, p < 0.001).
CONCLUSIONS: Both the intra- and inter-AEMD were significantly prolonged in the HOCM patients. PTSMA can improve the prolonged and inhomogeneous propagation of sinus impulses in atria.
Shi Chen; Jiansong Yuan; Jiafen Zhang; Shubin Qiao; Fujian Duan; Xiuzhang Lv; Fenghuan Hu; Weixian Yang; Yuejin Yang
Publication Detail:
Type:  Journal Article     Date:  2012-12-07
Journal Detail:
Title:  Cardiology     Volume:  123     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-05-30     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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MeSH Terms
Cardiomyopathy, Hypertrophic / physiopathology*,  surgery,  ultrasonography
Case-Control Studies
Catheter Ablation*
Follow-Up Studies
Heart Conduction System / physiopathology*
Middle Aged
Treatment Outcome
Comment In:
Cardiology. 2013;124(4):260   [PMID:  23571717 ]
Cardiology. 2013;124(4):259   [PMID:  23571668 ]

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