| Assessing vascular response to exercise using a combination of real-time spiral phase contrast MR and noninvasive blood pressure measurements. | |
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MedLine Citation:
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PMID: 20373446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To measure the hemodynamic response to exercise using real-time velocity mapping magnetic resonance imaging (MRI), incorporating a high temporal resolution spiral phase contrast (PC) sequence accelerated with sensitivity encoding (SENSE). MATERIALS AND METHODS: Twenty healthy adults underwent MRI at rest and during supine exercise at two different exercise levels. Flow volumes were assessed in the ascending aorta using a spiral SENSE real-time PC sequence. The sequence was validated at rest against a vendor supplied gated PC sequence, and also at rest and during exercise against left ventricular volumes assessed using a radial k-t SENSE real-time sequence. Combining the measured flow volumes with simultaneous oscillometric blood pressure measurements, enabled the noninvasive calculations of systemic vascular resistance (SVR) and arterial compliance (C). RESULTS: Measured flow volumes correlated very well between the sequences at rest and during exercise. Cardiac output (CO) and heart rate were found to significantly increase during exercise, while SVR and C were found to decrease significantly. CONCLUSION: Hemodynamic response to exercise can be accurately quantified using a high temporal resolution spiral SENSE real-time flow imaging. This may allow early detection of hypertension and a greater understanding of the early changes in this condition. |
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Authors:
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Jennifer A Steeden; David Atkinson; Andrew M Taylor; Vivek Muthurangu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 997-1003 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Centre for Medical Image Computing, UCL Department of Medical Physics & Bioengineering, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aorta / pathology Artifacts Blood Flow Velocity / physiology* Blood Pressure Female Heart Rate Hemodynamics Humans Magnetic Resonance Imaging / methods* Male Middle Aged Phantoms, Imaging Reproducibility of Results Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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