Document Detail

Assessing vascular response to exercise using a combination of real-time spiral phase contrast MR and noninvasive blood pressure measurements.
MedLine Citation:
PMID:  20373446     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To measure the hemodynamic response to exercise using real-time velocity mapping magnetic resonance imaging (MRI), incorporating a high temporal resolution spiral phase contrast (PC) sequence accelerated with sensitivity encoding (SENSE).
MATERIALS AND METHODS: Twenty healthy adults underwent MRI at rest and during supine exercise at two different exercise levels. Flow volumes were assessed in the ascending aorta using a spiral SENSE real-time PC sequence. The sequence was validated at rest against a vendor supplied gated PC sequence, and also at rest and during exercise against left ventricular volumes assessed using a radial k-t SENSE real-time sequence. Combining the measured flow volumes with simultaneous oscillometric blood pressure measurements, enabled the noninvasive calculations of systemic vascular resistance (SVR) and arterial compliance (C).
RESULTS: Measured flow volumes correlated very well between the sequences at rest and during exercise. Cardiac output (CO) and heart rate were found to significantly increase during exercise, while SVR and C were found to decrease significantly.
CONCLUSION: Hemodynamic response to exercise can be accurately quantified using a high temporal resolution spiral SENSE real-time flow imaging. This may allow early detection of hypertension and a greater understanding of the early changes in this condition.
Jennifer A Steeden; David Atkinson; Andrew M Taylor; Vivek Muthurangu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  31     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-10-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  997-1003     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
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MeSH Terms
Aorta / pathology
Blood Flow Velocity / physiology*
Blood Pressure
Heart Rate
Magnetic Resonance Imaging / methods*
Middle Aged
Phantoms, Imaging
Reproducibility of Results
Time Factors
Grant Support
FS/08/012/24454//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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