| Assessing the utility of atypical antipsychotic medication in adults with mild mental retardation and comorbid psychiatric disorders. | |
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MedLine Citation:
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PMID: 15669889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Research on psychiatric outcomes among individuals dually diagnosed with mild mental retardation and co-occurring mental illness who are treated with antipsychotic medication is markedly limited due to difficulties encountered in (1) making valid and reliable psychiatric diagnoses and (2) accurately rating and following psychiatric symptom change over time in this specialty population. METHOD: To address these issues, DSM-IV psychiatric diagnoses were made by an experienced dual-diagnosis clinician, and the Aberrant Behavior Checklist (ABC) and the Global Assessment of Functioning were used to assess behavioral and psychiatric features in a psychiatric partial hospital setting. Data were collected by chart review from 72 patients admitted consecutively from January 1998 to December 1999. Assessments were compared at admission and discharge in this retrospective study for 3 treatment groups that were defined by antipsychotic medication status at discharge: no antipsychotic (N = 15), atypical antipsychotic only (N = 41), and mixed atypical/typical antipsychotics or typical anti-psychotic only (N = 16). RESULTS: Improvement on the ABC social withdrawal subscale was greater for atypical anti-psychotic medication-treated, dually diagnosed patients than for those who received other treatment regimens. In addition, a dose-response relationship was observed for this subscale and atypical antipsychotic medication dose. CONCLUSION: For certain psychotic patients with mild mental retardation, the atypical antipsychotics may be an appropriate and effective treatment modality. |
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Authors:
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Karen J Shedlack; John Hennen; Christine Magee; Daniel M Cheron |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 66 ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-26 Completed Date: 2005-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 52-62 Citation Subset: IM |
Affiliation:
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Developmental Disabilities Program, McLean Hospital, Belmont, MA 02478, USA. k.shedlack@comcast.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use* Comorbidity Diagnostic and Statistical Manual of Mental Disorders Dose-Response Relationship, Drug Drug Administration Schedule Female Hospitalization Humans Male Mental Disorders / diagnosis, drug therapy*, epidemiology* Mental Retardation / epidemiology*, psychology Middle Aged Psychiatric Status Rating Scales Psychotic Disorders / diagnosis, drug therapy, epidemiology Retrospective Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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