Document Detail

Assessing supraspinal modulation of pain perception in individuals at risk for hypertension.
MedLine Citation:
PMID:  11321611     Owner:  NLM     Status:  MEDLINE    
In this study we tested the hypothesis that hypoalgesia in individuals at risk for hypertension is related to enhanced activation of supraspinal pain modulation systems. Supraspinal inhibition of pain signals was assessed using a diffuse noxious inhibitory control paradigm, in which a noxious conditioning stimulus was used to suppress pain in response to a noxious test stimulus applied to a remote area of the body. Specifically, the nociceptive flexion reflex (NFR) was assessed in 113 healthy young adults before, during, and after exposure to forearm tourniquet ischemia. Consistent with previous evidence of hypoalgesia in individuals at risk for hypertension, offspring of hypertensive individuals exhibited significantly higher NFR thresholds than offspring of normotensive persons. Although NFR activity was significantly decreased in all participants during concomitant application of forearm ischemia, the degree of attenuation of NFR activity was not significantly different as a function of risk for hypertension.
C R France; S Suchowiecki
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  38     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-04-25     Completed Date:  2001-05-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Department of Psychology, Ohio University, Athens 45701, USA.
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MeSH Terms
Hypertension / genetics,  psychology*
Pain / genetics,  psychology*
Pain Measurement
Pain Threshold / physiology
Spinal Cord / physiology*

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