| Assessing the sensory role of nicotine in cigarette smoking. | |
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MedLine Citation:
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PMID: 8880944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-two subjects were tested in five double-blind sessions (16 subjects in the morning following overnight smoking abstention, and 16 in the afternoon following ad-lib smoking). In each session, subjects smoked one of five experimental (EX) cigarettes having the following FTC nicotine/"tar' yields in mg: 0.08/8.5, 0.17/9.1, 0.37/9.8, 0.48/9.8, and 0.74/10.4. In a sixth session, subjects smoked a 0.71/8.6 commercial "light' (CL) cigarette that was their usual brand. Before and after smoking, subjects subjectively rated their desire to smoke a cigarette of their usual brand and had blood samples drawn. Following smoking, subjects rated the cigarette on a variety of sensory dimensions; they also rated smoking satisfaction. Analysis of variance indicated that nicotine played an important sensory role for a variety of dimensions related to cigarette taste and sensory impact but not perceived draw. Principal-components analyses indicated that sensory factors were at least as important as nicotine pharmacology (indirectly indexed by the pre-to post-smoking rise in blood nicotine concentration) when considering smoking's overall effects on satisfaction, product acceptance, and reduction in desire to smoke. |
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Authors:
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W S Pritchard; J H Robinson; T D Guy; R A Davis; M F Stiles |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Psychopharmacology Volume: 127 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-01-10 Completed Date: 1997-01-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 55-62 Citation Subset: IM |
Affiliation:
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Psychophysiology Laboratory, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Humans Male Mouth Nicotine / blood, pharmacology* Nose Pharynx Sensation / drug effects Smoking* / psychology Taste / drug effects |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
| Comments/Corrections | |
Erratum In:
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Psychopharmacology (Berl) 1996 Dec;128(4):432 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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