Document Detail

Assessing the sensory role of nicotine in cigarette smoking.
MedLine Citation:
PMID:  8880944     Owner:  NLM     Status:  MEDLINE    
Thirty-two subjects were tested in five double-blind sessions (16 subjects in the morning following overnight smoking abstention, and 16 in the afternoon following ad-lib smoking). In each session, subjects smoked one of five experimental (EX) cigarettes having the following FTC nicotine/"tar' yields in mg: 0.08/8.5, 0.17/9.1, 0.37/9.8, 0.48/9.8, and 0.74/10.4. In a sixth session, subjects smoked a 0.71/8.6 commercial "light' (CL) cigarette that was their usual brand. Before and after smoking, subjects subjectively rated their desire to smoke a cigarette of their usual brand and had blood samples drawn. Following smoking, subjects rated the cigarette on a variety of sensory dimensions; they also rated smoking satisfaction. Analysis of variance indicated that nicotine played an important sensory role for a variety of dimensions related to cigarette taste and sensory impact but not perceived draw. Principal-components analyses indicated that sensory factors were at least as important as nicotine pharmacology (indirectly indexed by the pre-to post-smoking rise in blood nicotine concentration) when considering smoking's overall effects on satisfaction, product acceptance, and reduction in desire to smoke.
W S Pritchard; J H Robinson; T D Guy; R A Davis; M F Stiles
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  127     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Psychophysiology Laboratory, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA.
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MeSH Terms
Double-Blind Method
Nicotine / blood,  pharmacology*
Sensation / drug effects
Smoking* / psychology
Taste / drug effects
Reg. No./Substance:
Erratum In:
Psychopharmacology (Berl) 1996 Dec;128(4):432

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