Document Detail


Assessing the relationship between preterm delivery and various microorganisms recovered from the lower genital tract.
MedLine Citation:
PMID:  16801313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if the likelihood of preterm delivery is more dependent on the specific organisms present in the vagina than on the presence of bacterial vaginosis. METHODS: We evaluated the vaginal fluid of a prospective cohort of women at 23-32 weeks of gestation with signs and symptoms of preterm labor and intact membranes. Forward stepwise logistic regression models were used to evaluate the relationship between preterm delivery and the presence of anaerobic bacteria, Gardnerella, ureaplasmas and mycoplasmas, and sialidase. RESULTS: The cohort included 137 women, and complete delivery information was available for 134 of them. The rate of preterm delivery was 28% (37 of 134). Mycoplasma genitalium independently was associated with spontaneous preterm delivery (OR 3.48; 95% CI 1.41, 8.57). After controlling for this factor, none of the other variables were significantly prognostic for spontaneous preterm delivery (residual overall p = 0.19). CONCLUSION: The presence of Mycoplasma genitalium in the vagina of pregnant women is an independent risk factor for spontaneous preterm delivery.
Authors:
Rodney K Edwards; Ronald J Ferguson; Leticia Reyes; Mary Brown; Douglas W Theriaque; Patrick Duff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  19     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-27     Completed Date:  2006-11-28     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA. edwardsr@obgyn.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Female
Humans
Mycoplasma genitalium / isolation & purification*
Obstetric Labor, Premature / etiology,  microbiology*
Pregnancy
Pregnancy Complications, Infectious / microbiology*
Prospective Studies
Risk Factors
Vagina / microbiology*
Vaginosis, Bacterial / complications,  microbiology*
Grant Support
ID/Acronym/Agency:
M01-RR00082/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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