Document Detail


Assessing the relationship between maternal opiate use and neonatal mortality.
MedLine Citation:
PMID:  9744134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
FINDINGS: The pooled estimates of the relative risks of neonatal mortality for separate heroin and methadone use were both near unity: 1.47 (95% CI 0.88-2.33) and 1.75 (95% CI 0.60-4.59), respectively. The result for heroin may be due to the inclusion in the meta-analysis of a particularly large study, which, unlike the two other smaller studies included found a relative risk near unity. When this study was excluded from the meta-analysis the pooled estimate of the relative risk of neonatal mortality for heroin use was 3.27 (95% CI 0.95-9.60). In contrast to the results for use of methadone only, the pooled relative risk associated with heroin and methadone use was 6.37 (95% CI 2.57-14.68).
CONCLUSIONS: The increased relative risk for neonatal mortality associated with women using heroin and methadone during pregnancy, compared to those stabilized on methadone, is probably due to the chaotic and high-risk life-style associated with illicit heroin use and not solely to the use of heroin and methadone per se. It is recommended tht women who use heroin well into pregnancy with late entry into methadone treatment, or who continue to use illicit heroin during pregnancy while receiving methadone, receive special attention over and above that provided to women stabilized on methadone.
Authors:
G K Hulse; E Milne; D R English; C D Holman
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Addiction (Abingdon, England)     Volume:  93     ISSN:  0965-2140     ISO Abbreviation:  Addiction     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-06     Completed Date:  1998-10-06     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9304118     Medline TA:  Addiction     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1033-42     Citation Subset:  IM    
Affiliation:
Department of Public Health, Faculty of Medicine and Dentistry, University of Western Australia, Australia. ghulse@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Female
Heroin
Humans
Infant Mortality*
Infant, Newborn
Methadone / therapeutic use
Narcotics / therapeutic use
Opioid-Related Disorders* / rehabilitation
Pregnancy
Pregnancy Complications* / rehabilitation
Risk
Chemical
Reg. No./Substance:
0/Narcotics; 561-27-3/Heroin; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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