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ASSESSING MULTILOCUS INTROGRESSION PATTERNS: A CASE STUDY ON THE MOUSE X CHROMOSOME IN CENTRAL EUROPE.
MedLine Citation:
PMID:  21521193     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Multilocus hybrid zone (HZ) studies predate genomics by decades. The power of early methods is becoming apparent and now large datasets are commonplace. Relating introgression along a chromosome to evolutionary process is challenging: although reduced introgression regions may indicate speciation genes, this pattern may be obscured by asymmetric introgression of linked invasive genes. Further, HZ movement may form salients and leave islands in its wake. Barton's concordance was proposed 24 years ago for assessing introgression where geographic patterns are complex. The geographic axis of introgression is replaced with the hybrid index. We compare this, a recently proposed genomic clines approach, and two-dimensional (2D) geographic analyses, for 24 X chromosome loci of 2873 mice from the central-European house mouse HZ. In 2D, 14 loci show linear contact, seven precisely matching previous studies. Four show introgression islands to the east of the zone, suggesting past westward zone movement, two show westward salients. Barton's concordance both recovers and refines this information. A region of reduced introgression on the central X is supported, despite X centromere-proximal male-biased westward introgression matching a westward 2D geographic salient. Genomic clines results are consistent regarding introgression asymmetries, but otherwise more difficult to interpret. Evidence for genetic conflict is discussed.
Authors:
Miloš Macholán; Stuart J E Baird; Petra Dufková; Pavel Munclinger; Barbora Vošlajerová Bímová; Jaroslav Piálek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-3
Journal Detail:
Title:  Evolution; international journal of organic evolution     Volume:  65     ISSN:  1558-5646     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373224     Medline TA:  Evolution     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1428-1446     Citation Subset:  -    
Copyright Information:
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Affiliation:
Laboratory of Mammalian Evolutionary Genetics, Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Brno, Czech Republic E-mail: macholan@iach.cz CIBIO, University of Porto, Campus Agrário de Vairão, Vairão, Portugal Department of Population Biology, Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic Department of Genetics, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic Biodiversity Research Group, Department of Zoology, Faculty of Science, Charles University in Prague, Czech Republic.
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