Document Detail

Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates.
MedLine Citation:
PMID:  18855973     Owner:  NLM     Status:  MEDLINE    
Inorganic nanoparticles (NPs) show great potential for medicinal therapy. However, biocompatibility studies are essential to determine if they are safe. Here, five different NPs are compared for their cytotoxicity, internalization, aggregation in medium, and reactive oxygen species (ROS) production, using tumoral and normal human blood cells. Differences depending on the cell type are analyzed, and no direct correlation between ROS production and cell toxicity is found. Results are discussed with the aim of standardizing the procedures for the evaluation of the toxicity.
Belén Díaz; Christian Sánchez-Espinel; Manuel Arruebo; José Faro; Encarnación de Miguel; Susana Magadán; Clara Yagüe; Rodrigo Fernández-Pacheco; M Ricardo Ibarra; Jesús Santamaría; Africa González-Fernández
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  4     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2025-34     Citation Subset:  IM    
Faculty of Biology, University of Vigo, Vigo, Pontevedra, Spain.
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MeSH Terms
Blood Cells / cytology*,  drug effects
Cell Line
Nanoparticles / chemistry*,  toxicity
Oxidative Stress / physiology
Particle Size
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Reactive Oxygen Species

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