Document Detail

Assessing the interstitial cells of Cajal, cells of enteric nervous system and neurotransmitters in slow transit constipation, using immunohistochemistry for CD117, PGP9.5 and serotonin.
MedLine Citation:
PMID:  20214215     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Slow transit constipation is one of the common causes of chronic constipation, in which the intestinal diameter is normal, but its transit time is markedly increased. The underlying cause in this disease is not definitely understood. METHODOLOGY: In this study was investigated the difference in the quantity of pace maker cells, cells of enteric nervous system and serotonin positive cells in normal colon and colon of the patients with slow transit constipation by using immunohistochemistry for c-Kit, PGP 9.5 and serotonin. RESULTS: The number of c-Kit positive pacemaker cells in the muscular layer was significantly decreased in the patients with slow transit constipation. PGP 9.5 positive enteric nervous system cells were significantly decreased in the patients with slow transit constipation in inner circular layer. Number of serotonin positive cells in the patients with slow transit constipation was significantly increased. CONCLUSIONS: Slow transit constipation is most probably a true enteric neuropathy.
Bita Geramizadeh; Kamran Hayati; Marjan Rahsaz; Seyed-Vahid Hosseini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  56     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1670-4     Citation Subset:  IM    
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Cell Count
Chronic Disease
Constipation / metabolism,  pathology*
Enteric Nervous System / cytology*
Interstitial Cells of Cajal / cytology*
Middle Aged
Neurotransmitter Agents / analysis*
Proto-Oncogene Proteins c-kit / analysis*
Serotonin / analysis*
Ubiquitin Thiolesterase / analysis*
Reg. No./Substance:
0/Neurotransmitter Agents; 50-67-9/Serotonin; EC Proteins c-kit; EC protein, human; EC Thiolesterase

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