Document Detail

Assessing iPSC reprogramming methods for their suitability in translational medicine.
MedLine Citation:
PMID:  22573568     Owner:  NLM     Status:  MEDLINE    
The discovery of the ability to induce somatic cells to a pluripotent state through the overexpression of specific transcription factors has the potential to transform the ways in which pharmaceutical agents and cellular transplantation therapies are developed. Proper utilization of the technology to generate induced pluripotent stem cells (iPSCs) requires that researchers select the appropriate reprogramming method for generating iPSCs so that the resulting iPSCs can be transitioned towards clinical applications effectively. This article reviews all of the currently available reprogramming techniques with a focus on critiquing them on the basis of their utility in translational medicine.
Mahendra S Rao; Nasir Malik
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  113     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-01-07     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3061-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc. This article is a U.S. Government work and is in the public domain in the USA.
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Laboratory of Stem Cell Biology, Bethesda, MD, USA.
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MeSH Terms
Cell Differentiation*
Cell Engineering / methods*
Genetic Vectors / genetics,  metabolism
Induced Pluripotent Stem Cells / cytology*,  metabolism
Lentivirus / genetics,  metabolism
MicroRNAs / genetics,  metabolism
Plasmids / genetics,  metabolism
RNA, Messenger / genetics,  metabolism
Regenerative Medicine
Reproducibility of Results
Translational Medical Research / methods*
Grant Support
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Messenger

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