Document Detail


Assessing iPSC reprogramming methods for their suitability in translational medicine.
MedLine Citation:
PMID:  22573568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of the ability to induce somatic cells to a pluripotent state through the overexpression of specific transcription factors has the potential to transform the ways in which pharmaceutical agents and cellular transplantation therapies are developed. Proper utilization of the technology to generate induced pluripotent stem cells (iPSCs) requires that researchers select the appropriate reprogramming method for generating iPSCs so that the resulting iPSCs can be transitioned towards clinical applications effectively. This article reviews all of the currently available reprogramming techniques with a focus on critiquing them on the basis of their utility in translational medicine.
Authors:
Mahendra S Rao; Nasir Malik
Related Documents :
15138938 - Cell proliferation and ultrastructural changes of the duodenal mucosa of patients affec...
16961808 - Helicobacter pylori infection and caga protein translocation in human primary gastric e...
21664138 - New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
11966528 - Inhibition of proliferation of gastric epithelial cells by a cyclooxygenase 2 inhibitor...
7689948 - Insulin-like growth factor binding protein-3 gene expression is restricted to involutin...
21423008 - Hedgehog signaling in cholangiocytes.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  113     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-01-07     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3061-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc. This article is a U.S. Government work and is in the public domain in the USA.
Affiliation:
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Laboratory of Stem Cell Biology, Bethesda, MD, USA. raomah@mail.nih.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Differentiation*
Cell Engineering / methods*
Genetic Vectors / genetics,  metabolism
Induced Pluripotent Stem Cells / cytology*,  metabolism
Lentivirus / genetics,  metabolism
MicroRNAs / genetics,  metabolism
Plasmids / genetics,  metabolism
RNA, Messenger / genetics,  metabolism
Regenerative Medicine
Reproducibility of Results
Transfection
Transgenes
Translational Medical Research / methods*
Grant Support
ID/Acronym/Agency:
ZIA AR041193-02/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Messenger
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Skull Mechanics and the Evolutionary Patterns of the Otic Notch Closure in Capitosaurs (Amphibia: Te...
Next Document:  Fabrication and drug release study of double-layered microparticles of various sizes.