Document Detail


Assessing health risks of inhaled nanomaterials: development of pulmonary bioassay hazard studies.
MedLine Citation:
PMID:  20665009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This brief discussion provides an overview of current concepts and perceptions regarding the pulmonary toxicity of ultrafine or nanoparticles. These aspects include, but are not limited to comparisons of fine particle vs. ultrafine particle effects and the unique response of pulmonary effects in rats vs. other rodent species, particularly at particle overload concentrations. In the final section, two studies are described which demonstrate that particle size is not the most significant particulate factor in producing exposure-related pulmonary effects.
Authors:
David B Warheit
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-28
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  398     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Affiliation:
DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, P.O. Box 50, Newark, Delaware 19714-0050, USA. David.B.Warheit@USA.dupont.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Lung / pathology*
Nanostructures / adverse effects,  chemistry,  toxicity*
Particle Size
Risk Assessment
Toxicology / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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