| Assessing health-related quality of life in generalized anxiety disorder using the Quality Of Life Enjoyment and Satisfaction Questionnaire. | |
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MedLine Citation:
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PMID: 19707153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Generalized anxiety disorder (GAD) is a chronic illness that leads to substantial impairments in quality of life. This post-hoc analysis used combined data from three 8-week quetiapine extended-release trials to investigate the reliability, validity, and responsiveness of the Short Form of the Quality of Life Enjoyment and Satisfaction Questionnaire [Q-LES-Q (SF)] in 2588 patients with GAD. The baseline Q-LES-Q (SF) score showed a Cronbach's alpha value of 0.86, indicative of reliability. Validity analyses for Q-LES-Q (SF) identified significant correlations with clinical efficacy measures (r>0.34 at week 8; P<0.001) and significant discrimination between patient groups categorized by symptom severity (P<0.001). Responsiveness was shown by significant differences in mean changes in Q-LES-Q (SF) scores at week 8 between patients defined according to the Hamilton Rating Scale for Anxiety response or remission criteria (P<0.001). The minimum clinically important Q-LES-Q (SF) score change was identified to be 6.80 points. Using this definition, response rates were significantly greater with quetiapine extended-release 150 mg versus placebo in individual trials and the combined population (P < or = 0.02). This analysis shows the overall reliability, validity, and responsiveness of the Q-LES-Q (SF) as a measure of overall quality of life and satisfaction in patients with GAD. |
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Authors:
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Kathleen Wyrwich; Neesha Harnam; Dennis A Revicki; Julie C Locklear; Henrik Sveds??ter; Jean Endicott |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: International clinical psychopharmacology Volume: 24 ISSN: 1473-5857 ISO Abbreviation: Int Clin Psychopharmacol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609061 Medline TA: Int Clin Psychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 289-95 Citation Subset: IM |
Affiliation:
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United BioSource Corporation, Bethesda, Maryland 20814, USA. kathy.wyrwich@unitedbiosource.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anxiety Disorders / drug therapy, psychology* Delayed-Action Preparations Dibenzothiazepines / administration & dosage Female Humans Male Middle Aged Quality of Life / psychology* Questionnaires* Randomized Controlled Trials as Topic Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Dibenzothiazepines; 0/quetiapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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