| Assessing functional outcomes following intracerebral hemorrhage in rats. | |
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MedLine Citation:
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PMID: 19464275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Translational neuroprotective and drug development studies need to be gauged against well-characterized functional outcomes, including motor, sensory and cognitive domains. Since intracerebral hemorrhage (ICH) causes dramatic neurological and cognitive deficits in humans, we hypothesized that ICH would result in prolonged motor-sensory and learning/memory deficits in rats. Neurological tests of sensorimotor functions were performed before ICH, 1-3 days and 10 weeks after ICH. Water maze, open field, and rotarod performance was tested 2 and 8 weeks after ICH. Early neurological evaluations revealed significant deficits, with almost full recovery by 10 weeks. The water maze revealed significant learning (but not motor) deficits at 2 weeks, but by 8 weeks, the learning deficits had diminished and significant motor deficits had emerged, coinciding with a drop in activity. The injured hemisphere showed significant atrophy at sacrifice. Therefore, ICH produced detectable cognitive and motor deficits in rats that evolved over a 10-week period, and thereby provides a suitable baseline for analysis of future therapeutic interventions following hemorrhagic stroke. |
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Authors:
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Richard Hartman; Tim Lekic; Hugo Rojas; Jiping Tang; John H Zhang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-05-21 |
Journal Detail:
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Title: Brain research Volume: 1280 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 148-57 Citation Subset: IM |
Affiliation:
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Department of Psychology, Loma Linda University Medical Center, Loma Linda, California, USA. behavioralneuroscience@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Analysis of Variance Animals Body Weight Brain / pathology Intracranial Hemorrhages / complications*, pathology Learning Disorders / etiology*, pathology Male Maze Learning Memory Disorders / etiology*, pathology Motor Activity Movement Disorders / etiology*, pathology Neuropsychological Tests Rats Rats, Sprague-Dawley Recovery of Function Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS43338/NS/NINDS NIH HHS; NS45694/NS/NINDS NIH HHS; NS53407/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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