Document Detail

Assessing endometrial hyperplasia and carcinoma treated with progestin therapy.
MedLine Citation:
PMID:  23010707     Owner:  NLM     Status:  In-Data-Review    
The effects of increased amounts of progesterone on the endometrium, including such features as eosinophilic cytoplasmic metaplasia, glandular atrophy, and decidualized stroma, are well-known among surgical pathologists. These changes are typically seen as secondary effects of pregnancy or exogenous hormone therapy for birth control purposes or abnormal bleeding. Treatment with progesterone has become a viable alternative to hysterectomy in some patients with complex atypical hyperplasia (CAH) and well-differentiated endometrial carcinoma (WDC), especially those who are poor surgical candidates or those wishing to preserve fertility. To date, only 1 study has specifically examined the effects of progestin therapy on patients with a previous diagnosis of CAH or WDC. That study proposed a classification scheme for the assessment of treated CAH and WDC. The authors concluded that after 6 months of treatment, endometrial biopsy findings of persistent cytologic atypia and architectural abnormalities were associated with treatment failure. This current study aims to assess the previously proposed criteria in a cohort of 30 patients (18 with a diagnosis of CAH and 12 with a diagnosis of WDC), and determine the usefulness of these criteria in clinical practice. Our study confirms that cytologic atypia after 6 months of therapy is strongly associated with treatment failure, and should be an indication to pursue definitive surgical treatment in these patients.
Mark J Mentrikoski; Akeesha A Shah; Krisztina Z Hanley; Kristen A Atkins
Related Documents :
12183777 - Early duplex-derived hemodynamic parameters after lower extremity bypass in diabetics: ...
24739147 - Temporal trends in the discontinuation of first-line antiretroviral therapy.
25021957 - Ptu-086 ulcerative colitis (uc) and anti-tumour necrosis factor (a-tnf) therapy; a si...
24355487 - Compliance and arthralgia in clinical therapy: the compact trial, assessing the inciden...
10850577 - Effect of the administration of recombinant activated factor vii (rfviia; novoseven) in...
22640467 - Patient outcomes and thoracic aortic volume and morphologic changes following thoracic ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  138     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-34     Citation Subset:  AIM; IM    
1215 Lee St, Charlottesville, VA 22903;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Follow-up Outcomes in a Large Cohort of Patients With Human Papillomavirus-Negative ASC-H Cervical S...
Next Document:  Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cance...