| Assessing diabetic foot ulcer development risk with hyperspectral tissue oximetry. | |
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MedLine Citation:
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PMID: 21361693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Foot ulceration remains a serious health concern for diabetic patients and has a major impact on the cost of diabetes treatment. Early detection and preventive care, such as offloading or improved hygiene, can greatly reduce the risk of further complications. We aim to assess the use of hyperspectral tissue oximetry in predicting the risk of diabetic foot ulcer formation. Tissue oximetry measurements are performed during several visits with hyperspectral imaging of the feet in type 1 and 2 diabetes mellitus subjects that are at risk for foot ulceration. The data are retrospectively analyzed at 21 sites that ulcerated during the course of our study and an ulceration prediction index is developed. Then, an image processing algorithm based on this index is implemented. This algorithm is able to predict tissue at risk of ulceration with a sensitivity and specificity of 95 and 80%, respectively, for images taken, on average, 58 days before tissue damage is apparent to the naked eye. Receiver operating characteristic analysis is also performed to give a range of sensitivity/specificity values resulting in a Q-value of 89%. |
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Authors:
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Dmitry Yudovsky; Aksone Nouvong; Kevin Schomacker; Laurent Pilon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical optics Volume: 16 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-02 Completed Date: 2011-06-02 Revised Date: 2012-02-13 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 026009 Citation Subset: IM |
Affiliation:
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University of California, Los Angeles, Henry Samueli School of Engineering and Applied Science Biomedical Inter-Department Program, Los Angeles, California 90095-1597, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Diabetic Foot / blood*, diagnosis* Equipment Design Equipment Failure Analysis Hemoglobins / analysis* Oximetry / instrumentation* Reproducibility of Results Sensitivity and Specificity Spectroscopy, Near-Infrared / instrumentation* |
| Grant Support | |
ID/Acronym/Agency:
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R42-DK069871/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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