Document Detail

Assessing the depth of hypnosis of xenon anaesthesia with the EEG.
MedLine Citation:
PMID:  20180643     Owner:  NLM     Status:  In-Process    
Xenon was approved as an inhaled anaesthetic in Germany in 2005 and in other countries of the European Union in 2007. Owing to its low blood/gas partition coefficient, xenons effects on the central nervous system show a fast onset and offset and, even after long xenon anaesthetics, the wake-up times are very short. The aim of this study was to examine which electroencephalogram (EEG) stages are reached during xenon application and whether these stages can be identified by an automatic EEG classification. Therefore, EEG recordings were performed during xenon anaesthetics (EEG monitor: Narcotrend®). A total of 300 EEG epochs were assessed visually with regard to the EEG stages. These epochs were also classified automatically by the EEG monitor Narcotrend® using multivariate algorithms. There was a high correlation between visual and automatic classification (Spearman's rank correlation coefficient r=0.957, prediction probability Pk=0.949). Furthermore, it was observed that very deep stages of hypnosis were reached which are characterised by EEG activity in the low frequency range (delta waves). The burst suppression pattern was not seen. In deep hypnosis, in contrast to the xenon EEG, the propofol EEG was characterised by a marked superimposed higher frequency activity. To ensure an optimised dosage for the single patient, anaesthetic machines for xenon should be combined with EEG monitoring. To date, only a few anaesthetic machines for xenon are available. Because of the high price of xenon, new and further developments of machines focus on optimizing xenon consumption.
Ralph Stuttmann; Arthur Schultz; Thomas Kneif; Terence Krauss; Barbara Schultz
Related Documents :
2941793 - Correlation-spectral characteristics of cortical potentials in a wide frequency range i...
10505383 - Predicting movement during anaesthesia by complexity analysis of electroencephalograms.
20007153 - Dependence of aptamer activity on opposed terminal extensions: improvement of light-reg...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedizinische Technik. Biomedical engineering     Volume:  55     ISSN:  1862-278X     ISO Abbreviation:  Biomed Tech (Berl)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1262533     Medline TA:  Biomed Tech (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Clinic of Anaesthesiology, Intensive Care and Emergency Medicine, Pain Centre, Berufsgenossenschaftliche Kliniken Bergmannstrost, Halle/Saale, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs.
Next Document:  Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing.