Document Detail


Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T2* mapping.
MedLine Citation:
PMID:  20170769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the sensitivity of ultra-short echo time (UTE) T(2)* mapping to collagen matrix degeneration in human articular cartilage.
METHODS: Magnetic resonance imaging (MRI) UTE-T(2)* maps and standard T(2) maps were acquired on four human tibial plateau explants. Thirty-three osteochondral cores were harvested for polarized light microscopy (PLM), and composition analyses. Collagen matrix integrity was evaluated from PLM and histological images. Matrix integrity and composition was compared to standard T(2) values and UTE-T(2)* values on a spatially registered basis.
RESULTS: UTE-T(2)* values varied with matrix degeneration (P=0.008) and were lower in severely degraded cartilage compared to healthy tissue (P=0.012). A trend for higher UTE-T(2)* values in healthy tissue compared to mildly degenerate tissue (P=0.051) was detected. Standard T(2) values were not found to vary with matrix degeneration (P=0.13) but tended to be higher in severely degraded cartilage compared to healthy tissue. UTE-T(2)* value variations were independent of type-II collagen and glycosaminoglycan contents. UTE-T(2)* mapping of deep cartilage, adjacent to subchondral bone, was more robust than standard T(2) mapping in this zone.
CONCLUSION: UTE-T(2)* mapping of articular cartilage is sensitive to matrix degeneration and detects short-T(2) signal, particularly in deep tissue, that is not well captured by standard T(2) mapping. Correlation of UTE-T(2)* values and PLM indices supports the hypothesis that both may be sensitive to collagen microstructure. Further exploration of UTE-T(2)* mapping as a non-invasive tool to detect early articular cartilage degeneration is warranted.
Authors:
A Williams; Y Qian; D Bear; C R Chu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-06
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  18     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-29     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  539-46     Citation Subset:  IM    
Copyright Information:
2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aged
Cadaver
Cartilage, Articular / pathology*
Echo-Planar Imaging / methods
Female
Humans
Knee Joint / pathology
Magnetic Resonance Imaging / methods*
Male
Microscopy, Polarization
Osteoarthritis, Knee / pathology*
Grant Support
ID/Acronym/Agency:
AR052784-03S1/AR/NIAMS NIH HHS; R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784-01A1/AR/NIAMS NIH HHS; R01 AR052784-02/AR/NIAMS NIH HHS; R01 AR052784-03/AR/NIAMS NIH HHS; R01 AR052784-03S1/AR/NIAMS NIH HHS; R01 AR052784-04/AR/NIAMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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