Document Detail

Assessing coronary plaque burden and plaque vulnerability: atherosclerosis imaging with IVUS and emerging noninvasive modalities.
MedLine Citation:
PMID:  15815137     Owner:  NLM     Status:  MEDLINE    
Despite significantly improved preventive and therapeutic options, coronary artery disease remains the major cause of mortality in North America. A large number of acute coronary events, including acute myocardial infarction and sudden cardiac death, occur in patients without prior symptoms because these events are initiated by sudden rupture of mildly stenotic but vulnerable lesions. Recent results demonstrate a high prevalence of such plaques many years before clinical events occur. Because these lesions are mildly stenotic before the event, the angiographic evaluation of the lumen is not sufficient for their detection. Therefore, direct observation of coronary plaque burden and plaque vulnerability with in vivo tomographic imaging modalities is increasingly utilized. Intravascular ultrasound is the most established invasive method with a long clinical track record. More recently, noninvasive modalities including computed tomography and magnetic resonance imaging are emerging.
Paul Schoenhagen; Steven E Nissen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American heart hospital journal     Volume:  1     ISSN:  1541-9215     ISO Abbreviation:  Am Heart Hosp J     Publication Date:  2003  
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101156064     Medline TA:  Am Heart Hosp J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Department of Cardiovascular Medicine and Radiology, Section of Cardiovascular Imaging, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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MeSH Terms
Acute Disease
Coronary Artery Disease / physiopathology,  ultrasonography*
Coronary Vessels / ultrasonography
Diagnostic Techniques, Cardiovascular
Disease Progression
Risk Factors
Ultrasonography, Interventional / methods*

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