| Assessing circadian rhythms in propofol PK and PD during prolonged infusion in ICU patients. | |
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MedLine Citation:
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PMID: 20544262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates possible circadian rhythms during prolonged propofol infusion in patients in the intensive care unit. Eleven patients were sedated with a constant propofol infusion. The blood samples for the propofol assay were collected every hour during the second day, the third day, and after the termination of the propofol infusion. Values of electroencephalographic bispectral index (BIS), arterial blood pressure, heart rate, blood oxygen saturation and body temperature were recorded every hour at the blood collection time points. A two-compartment model was used to describe propofol pharmacokinetics. Typical values of the central and peripheral volume of distribution and inter-compartmental clearance were V(C) = 27.7 l, V(T) = 801 l, and CL(D) = 2.73 l/min. The systolic blood pressure (SBP) was found to influence the propofol metabolic clearance according to Cl (l/min) = 2.65 x (1-0.00714 x (SBP-135)). There was no significant circadian rhythm detected with respect to propofol pharmacokinetics. The BIS score was assessed as a direct effect model with EC(50) equal 1.98 mg/l. There was no significant circadian rhythm detected within the BIS scores. We concluded that the light-dark cycle did not influence propofol pharmacokinetics and pharmacodynamics in intensive care units patients. The lack of night-day differences was also noted for systolic blood pressure, diastolic blood pressure and blood oxygenation. Circadian rhythms were detected for heart rate and body temperature, however they were severely disturbed from the pattern of healthy patients. |
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Authors:
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Agnieszka Bienert; Krzysztof Kusza; Katarzyna Wawrzyniak; Edmund Grześkowiak; Zenon J Kokot; Jan Matysiak; Tomasz Grabowski; Anna Wolc; Paweł Wiczling; Miłosz Regulski |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-11 |
Journal Detail:
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Title: Journal of pharmacokinetics and pharmacodynamics Volume: 37 ISSN: 1573-8744 ISO Abbreviation: J Pharmacokinet Pharmacodyn Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-09-22 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101096520 Medline TA: J Pharmacokinet Pharmacodyn Country: United States |
Other Details:
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Languages: eng Pagination: 289-304 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, ul. Marii Magdaleny 14, 61-861, Poznań, Poland. agnbienert@op.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anesthetics, Intravenous / administration & dosage, pharmacokinetics*, pharmacology* Blood Pressure / drug effects, physiology Body Temperature / drug effects, physiology Circadian Rhythm / drug effects, physiology* Electroencephalography / drug effects Female Heart Rate / drug effects, physiology Humans Infusions, Intravenous Intensive Care / methods* Male Middle Aged Models, Biological Oxygen / blood Propofol / administration & dosage, pharmacokinetics*, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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