| Assessing cerebrospinal fluid flow connectivity using 3D gradient echo phase contrast velocity encoded MRI. | |
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MedLine Citation:
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PMID: 21343652 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study is to investigate the feasibility of using three-directional velocity encoded 3D gradient echo (GE) phase contrast (PC) imaging to assess cerebrospinal fluid (CSF) flow connectivity in the human brain. Five healthy volunteers were scanned using low velocity sensitivity (V(enc) = 0.04-0.05 m s(-1)). Flow-time curves were compared to standard 2D PC scans. The 3D data were used to reconstruct in vivo CSF flow volumes based on time-averaged phase-difference information, and the patency of the CSF flow pathways was assessed using nearest-neighbour connectivity. A pulsatile flow phantom was used to gauge the measurement accuracy of the CSF flow volumes at low flow velocities. Flow connectivity from the lateral ventricles down to the cisterna magna was successfully demonstrated in all volunteers. The phantom tests showed a good distinction between the flow cavities and the background noise. 3D PC imaging results in CSF flow waveforms with similar pulsatility but underestimated peak velocities compared to 2D PC data. 3D time-resolved velocity encoded GE imaging has successfully been applied to assess CSF flow connectivity in normal subjects. |
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Authors:
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Henrik Odéen; Martin Uppman; Michael Markl; Bruce S Spottiswoode |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: Physiological measurement Volume: 32 ISSN: 1361-6579 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306921 Medline TA: Physiol Meas Country: - |
Other Details:
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Languages: ENG Pagination: 407-421 Citation Subset: - |
Affiliation:
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Lund Institute of Technology, Lund University, Box 118, 221 00 Lund, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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