| Assessing cell K physiology in hypertensive patients. A new clinical and methodologic approach. | |
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MedLine Citation:
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PMID: 16580582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The assessment of potassium (K) effects in hypertension involves a history of complex research in cell K function and body K homeostasis. These studies provide evidence for the role of K ions in vascular and renal function, insulin resistance, glucose uptake, and the renin-angiotensin-aldosterone system; and there have been an impressive number of clinical and epidemiologic research relating dietary intake K and regulation of blood pressure. However, the usual technique by which K metabolism is assessed in clinical practice (plasma or serum K) provides no useful data for estimating disorders in cell K transport that occurs in hypertensive patients or that may follow the administration of diuretics, beta-blockers, or nonsteroidal anti-inflammatory drugs. This fact becomes more crucial if associated with the physiologic decline in body K stores occurring after the age of 30 years, which may impair the long-term treatment of hypertensive individuals. In this context, this article presents a review of the clinical and research methods that can be used to assess more accurately K metabolism and cell K physiology in hypertensive patients, including a heritable defect in red blood cell K transport. |
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Authors:
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Antonio Delgado-Almeida |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: American journal of hypertension Volume: 19 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-08-22 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 432-6 Citation Subset: IM |
Affiliation:
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Hypertension Research Unit, University of Carabobo Medical School, Valencia, Venezuela. delgado_almeida@hypertensresearch.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Erythrocytes / metabolism* Homeostasis / physiology Humans Hypertension / blood, physiopathology* Insulin Resistance / physiology Kidney / physiology Phenotype Potassium / blood, physiology* Renin-Angiotensin System / physiology |
| Chemical | |
Reg. No./Substance:
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7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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