Document Detail

Assessing bone loss on radiographs of the knee in osteoarthritis: a cross-sectional study.
MedLine Citation:
PMID:  16255025     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The only established system to grade subchondral bone attrition in knee osteoarthritis (OA) has low interobserver reliability. In this study, our aim was to convert this system into a reliable tool for the assessment of subchondral bone loss in knee OA. METHODS: Templates that were designed to outline the normal contours of the knee were overlaid onto conventional radiographs of a random sample of 100 knees of OA patients who were awaiting total knee replacement (TKR). Seventy-five films from individuals with chronic knee pain who were not awaiting TKR and 75 films from asymptomatic control subjects were also assessed. Bone loss was graded from 0 (no attrition) to 3 (severe attrition of >10 mm); other established radiologic features were also graded. Spearman's rho was used to determine the correlation of attrition scores with other features, and logistic regression was used to explore whether definite bone attrition was associated with night pain. RESULTS: The inter- and intraobserver reliability values were high for attrition scores and for the presence of definite attrition (score > or =2). Bone attrition was evident in 62% of films from patients awaiting TKR, in 9% of films from individuals with chronic knee pain who were not awaiting TKR, and in 1% of films from controls. In all groups, the correlation between attrition and other features was weak to moderate. There was a nonsignificant association between definite bone attrition and night pain. CONCLUSION: Bone attrition is an additional dimension of knee OA that can be measured reliably. Definite attrition may be associated with night pain.
Paul A Dieppe; Stephan Reichenbach; Susan Williams; Paul Gregg; Iain Watt; Peter Jüni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  52     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-03     Completed Date:  2005-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3536-41     Citation Subset:  AIM; IM    
University of Bristol, Bristol, UK.
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MeSH Terms
Bone Resorption / epidemiology,  pathology,  radiography*
Chronic Disease
Cross-Sectional Studies
Knee Joint / pathology,  radiography*
Logistic Models
Observer Variation
Osteoarthritis, Knee / epidemiology,  pathology,  radiography*
Pain / epidemiology,  physiopathology
Single-Blind Method

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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